March 31 2017DOCOMOMO US National Symposium visit

first_imgMarch 31, 2017DOCOMOMO US National Symposium visits Arcosanti.The Docomomo US National Symposium is the primary event in the United States for professionals to discuss and share efforts to preserve modern architecture and meet leading practitioners and industry professionals.[photos by Leah-Ann Walker]The Fifth Annual Docomomo US National Symposium entitled “Modernism and Climate” is taking place in Phoenix, AZ from March 29. through April 2. 2017.It will look at how modern design approached desert climates creatively and how thos design strategies continue to be relevant in light of our search for sustainable solutions and what can be learned from those creative efforts.The only national event dedicated to all aspects of the preservation of Modernism, the symposium brings together world renowned designers, scholars, students and professionals from around the country.last_img read more

Contentwise is providing personalised recommendati

first_imgContentwise is providing personalised recommendations for Sky Italia’s Sky Online OTT TV service, launched earlier this year.Sky Online provides subscribers with access to a content catalogue including movies, sports and TV series.Sky Italia has targeted its subscription-based linear TV and on-demand service at non-Sky customers, particularly younger people. The service does not require a set-top box and is available via the web, iOS and Android devices, and via Xbox and PlayStation game consoles.ContentWise CEO Paolo Bozzola told DTVE that recommendation is one of the pillars in the design of the service. The company’s recommendation engine is supplied to the pay TV operator via Ericsson, which acted as system integrator for the project.Sky is offering a selection of live channels via two packages – on covering entertainment and the other covering movies – and on-demand content, including limited-duration passes to sports events.Bozzola said that recommendation is integrated into all aspects of the UI.“We try to put personalisation everywhere,” he said. Personalisation extends to features including the services list of the ‘most popular’ titles, with this list varying according to different categories of subscriber, according to Bozzola.Content can be pushed to subscribers through editorial recommendations as well as presented purely on the basis of past behaviour. ContentWise’s technology also predicts what viewers are likely to want to watch at certains times based on context.Bozzola said that ContentWise used a mix of techniques, including both past behaviour and metadata, to serve content to customers. He said that based on experience with other service providers, personalization can provide uplift in terms of on-demand consumption of the order of 30%.Bozzola said that ContentWise, whose existing customer base includes Mediaset and Telecom Italia as well as Germany’s Maxdome and TIM Brasil, expects to announce two new North American customers and one UK customer soon.ContentWise is not providing the search engine for the Sky Italia service, which is provided to Sky by an existing supplier.last_img read more

Good day And a Marvelous Monday to you Front and

first_imgGood day. And a Marvelous Monday to you! Front and Center. Happy Birthday to my darling daughter, Dawn. More at the end.  Cards lose in the 19th inning, they sure didn’t play very good baseball this weekend!  The weather was fabulosio this weekend in the St. Louis area, so we had that going for us. Chris heads to San Francisco later this week for the San Francisco Money Show.  I sure wish I were going too. I sure do love that city!Friday, we saw a lot of dollar buying to end the week. The currencies held the baton, orchestrating a gain for the week, until the dollar snuck up behind and snatched it away to end the week. The U. of Michigan Confidence report for the first two weeks of August, showed an increase and so did Leading Indicators for July. But I think it would be a stretch to think that those reports were the main reason the dollar rallied on Friday. Instead, I would think the reason could be placed squarely on the shoulders of book squaring.  But, the data didn’t hurt!This morning, the euro is a bit stronger, as most of the currencies are VS the U.S. dollar. The euro is getting a boost this morning from the rumors going around, that someone’s underground and, no wait! Darn-it Chuck, stick to the story! Well, the rumors this morning center around the ECB bond buying program, that just last week, Angela Merkel, said that Germany didn’t have any problems with, just might take place.The reports / rumors are talking about how the European Central Bank (ECB) is going to set limits for Eurozone debt yields, and pledge an unlimited amount of bond buying to maintain those limits. Whoa, there partner!  I sure hope they don’t make that announcement in public. Because I see all kinds of problems that could come of that! It’s far better to keep things like close to the vest and let the markets figure it out on their own.And Germany’s Central Bank, the Bundesbank, has opened up a line of criticism of the ECB, saying that “The Bundesbank holds to the opinion that government bond purchases by the Eurosystem are to be seen critically and entail significant stability risks.”Now. in the old days before the euro and the ECB were established. The Bundesbank was the cat’s meow. They controlled the monetary policy of the largest economy, and other central banks followed so closely to the Bundesbank that they could tell you what flavor gum the Bundesbankers were chewing! Holland, Denmark, Austria, and others had their central banks in the shadow of the Bundesbank. But. I’m afraid that’s all in the past. The ECB has the reins now. but, any kind of public debate will not be good for the euro.We have a couple of weeks before any decision is made there, as the ECB governing council will meet in September, and discuss this program. But, for now, the markets like what they’re hearing.  And the best performing currency overnight has been the Aussie dollar (A$). And after a week that saw the A$ lose ground, on statements by the Australian Treasurer about the currency being overvalued, the A$ fights to gain that lost ground back.  The Reserve Bank of Australia (RBA) meeting minutes will print tonight, so the markets will be going over those minutes to see if the RBA mentions the A$ strength.A Senior Currency Strategist at Westpac Banking Corp in Sydney had this to say about the A$… “While the Aussie might still be a little bit pricey at $1.04, I don’t think you want to be aggressive about short positions. I think the news out of Europe is getting a little better.”This is a big week in the Eurozone, as the German Chancellor (Merkel), and French President (Hollande) will meet this week, to discuss Greece. This meeting will come after both will have had separate meetings with Greek Prime Minister, (Samaras).   There is no revealing of Greece’s progress in cutting deficit spending / debt this week, that has to wait for the September publication of the Troika report on Greece’s progress. Remember, that if the Troika doesn’t believe that Greece has done enough they will hold back the next scheduled tranche of bailout funds for Greece.In addition, for those of you new to class. The Troika, is the name given to the members of the European Central Bank, The European Commission, and the IMF.  I know it might sound as though the rest of the Eurozone is ganging up on Greece, and being unfair to them. But. this framework was agreed to by the Greek leaders, in return for the second bailout funds.There’s not a lot of “meat” in the way of economic data reports this week in the U.S.  We will see some housing data, and Durable Goods later in the week. The biggest banana in the data bunch this week will be the meeting minutes of the last FOMC meeting.  Yes, all those notes will beU stale. but, will at least give the markets an idea of the frame of mind of the Fed Heads.OK.. moving along here. A dear reader, sent me a note the other day asking me, “if U.S. Treasury yields are rising, isn’t that good for the dollar?”  Well, yes, and no.  Yes, the dollar gets to fight with the other countries for yield differential trades. But, there’s a lot of trepidation here. how many false dawns have we seen in the past few years? Too many. too many times we’ve seen yields rise, only to be knocked back down again, and the markets are very well aware of that. So, they have not jumped in with both feet here. yet.  but if they do, they could give the dollar some love with the higher yields in Treasuries. But let me remind you what’s in the back of the minds of the market participants. The Fed participated in 61% of the Treasury auction last year. And they could turn the printing press on, and step up the buying at any time.  and for those of you that are going to throw a dart at me here. Yes,  I know there’s no actual printing press, it’s just a better way of describing the creation of dollars for the Fed to use to buy the Treasuries.I had another dear reader send me a note and to tell me how the Columbian economy is booming, and wanted me to list some Latin currencies in the currency roundup. Hmmm. if I keep adding currencies that list is going to get pretty large, and I’ll spend all morning, checking currency prices instead of writing!  But. We’ll add them to the Review & Focus currency dashboard. So, if you get the R&F, you’ll see them there starting in October. (we’ve already sent the September issue off to the printing press)  But I agree with the reader, Columbia has been on my list of countries that I’m watching, for over a year now. The currency is just so limited and fairly illiquid.  But that won’t stop me! I have a new MarketSafe CD coming out soon, get ready!The Japanese yen has been losing some ground in the past week.  As I told you in a Pfennig last week, the so-called “safe haven” destinations for money, that include yen, and Treasuries were getting sold.  Long time readers know that I threw in the towel on Japanese yen, as I kept saying that it was overvalued, and needed to weaken, and instead it would just get stronger VS the dollar. The Bank of Japan (BOJ) passed on their latest call for more stimulus at their last meeting, which didn’t help the yen.   I just think there are better currencies in Asia than yen. For the longest time, and I mean going back 20 years, when someone said they owned an Asian currency, you pretty much knew it was Japanese yen.  But it doesn’t have to be that way any longer!In that same vein. going back quite a few years. when someone said they owned a foreign currency, you pretty much knew they owned Swiss francs. (that is unless they recently took a trip to Canada or Mexico! HA!)  Swiss francs were the bees knees. But, then Switzerland was dwarfed by the Eurozone, and soon it became all about the euro. And. the Swiss National Bank (SNB) decided to hurt investors with a huge devaluation a year ago, and since then, we don’t get many people looking to buy francs.And then, I see where Bank of Canada (BOC) Gov. Carney will speak to Canadian Auto Workers Union this week.  You can bet that there will be calls to weaken the Canadian dollar / loonie. But, there’s not much the BOC can do. The loonie is stronger due to investors buying up Canadian bonds, as safe havens.  Now. in my opinion, which you know means I could be wrong, but in my opinion, Canada represents a safe haven much more than the Japanese yen, or U.S. Treasuries!  Yes, I truly understand that the size of the Japanese and U.S. bond markets dwarf Canada’s. But, given the strong banking sector in Canada, and the strong domestic demand of the economy, (we’ll see proof of that this week when Retail Sales prints) and steady government. safe haven is written all over Canada. again, that’s just my opinion!The price of Oil continues to climb higher, trading into the $96 handle this morning. There is talk now about the U.S. Gov’t releasing some of the oil reserves in an attempt to dampen the prices and prevent high energy costs, which could wipe out any gains the economy has made.Then There Was This. From The U.S. government’s debt held by foreign entities hit a record $5.2923 trillion in June, reported, citing Treasury Department data.In January 2009 the U.S. government owed $3.0717 trillion to foreigners entities, the news service added.China was the top creditor to the U.S. government, though Japanese entities were a close second.“Although the Chinese maintained their place as the top foreign owners of U.S. debt in June, they are not the top owners of U.S. debt in the world,” reported. “That distinction belongs to the U.S. Federal Reserve, which according to its July monthly report, owned $1.667 trillion in U.S. government debt in June.”Chuck again. I don’t know what scares me more. having so much of our debt held by foreigners, or by our own central bank!   I hear you saying, who do you want to own out debt, Chuck?  I don’t want debt to have to own!  Knowing that’s nearly impossible, I don’t know. I just don’t know. it’s like we’ve painted ourselves into a corner. if we step to the right, it’s bad, and if we step to the left it’s bad.  But then, I began warning about the growing debt in 2001.To recap. the currencies folded like a cheap tent on Friday to the dollar. Some second tier economic data was good for the dollar, but it had to be more than that driving the dollar higher. This morning, the currencies are attempting a move back at the dollar, as the ECB plan to buy bonds, is gaining traction, except with the Bundesbank.  The Aussie dollar is stronger this morning, and the RBA meeting minutes could give us a clue about the RBA’s feeling toward the strong A$.Currencies Today 8/20/12. American Style: A$ $1.0450, kiwi .8085, C$ $1.0115, euro 1.2310, sterling 1.5695, Swiss $1.0250, . European Style: rand 8.3120, krone 5.9370, SEK 6.6810, forint 225.65, zloty 3.3065, koruna 20.2370, RUB 32.08, yen 79.50, sing 1.2545, HKD 7.7570, INR 55.75, China 6.3590, pesos 13.10, BRL 2.0145, Dollar Index 82.63, Oil $96.13, 10-year 1.85%, Silver $28.14, and Gold $1,615.30That’s it for today. Yes, I won’t say how old my darling daughter Dawn is today, but she’s still looks like a young lady! Dawn shares a birthday, with our little Christine’s son, Jamieson. And Dawn’s college roommate, Kat, was in town yesterday, and it was her birthday, so we sang Happy Birthday to Dawn & Kat! So, birthdays all around!  The college football talk is really heating up, with all the anticipation of my beloved Missouri Tigers moving to the SEC this year. I sure hope they can be respectable in that league! It was great seeing Kat yesterday. When she attended Mizzou with Dawn, she came home with Dawn all the time, and it was like I had two daughters.  Oh, and Dawn’s husband, Jerry, wanted to be mentioned this morning too. HA!  I hope you all have a Marvelous Monday!Chuck Butler President EverBank World Markets 1-800-926-4922 read more

And one that seems particularly appropriate At

first_img And one that seems particularly appropriate: At 73, I can attest to the fact it is been a fun ride so far, and I am having too much fun to even think about getting off. Until next week… Our wealth is disappearing, and we need to speak up now. In a recent article for the Casey Daily Dispatch, I took Obama’s budget proposal and the effect it would have on Social Security to task. The president’s proposal offers three alternatives for funding Social Security – the Chained CPI; an expanded Social Security tax; or additional limits on IRA and 401(k) contributions. I don’t like any of these “solutions” one bit. In a recent Wall Street Journal article, Kelly Greene and Vipal Monga reported that pensions represent an increasingly smaller portion of Americans’ retirement savings. The authors wrote: “The portion of private-sector US workers covered only by so-called defined-benefit plans fell to 3% in 2011 from 28% in 1979, according to US Department of Labor data compiled by EBRI.” Unless you work for the government, pensions have gone the way of the dodo bird. Private-sector employers have switched from defined benefit plans to defined savings plans like 401(k)s and IRAs. If you don’t want to end up trying to survive on Social Security alone, you’re going to have to save quite a bit of money. And the financial shenanigans our government likes to pull make retiring even tougher. As I mentioned in my book, Retirement Reboot, when the government bailed out “too big to fail” banks, my retirement plan had to change radically. Treasuries and FDIC-insured CDs paying three times the inflation rate went out the window. Those safe, high-yield investments have gone the way of private-sector pension plans. To make matters worse, our annual Social Security cost of living increases don’t come close to covering rising expenses. The Chained CPI, moreover, would only further jerry-rig benefits, helping the spendthrift federal government at our expense. Many seniors have already taken a huge income cut as their portfolios struggle. Recently, my wife Jo and I looked at a 55-plus community on the outskirts of Phoenix. It was a pretty, upscale community – one we might be interested in. When Jo pulled up information on the community, some of data highlighted how much retirees are struggling. The statistics were: Population in 2010: 1,811 Population change since 2000: + 27.6% Median age of residents: 70.4 Estimated median household income in 2000: $86,248 Estimated median household income in 2009: $73,875 According to the Bureau of Labor Statistics’ (BLS) inflation calculator, if one had an income of $86,248 in 2000, one would have to earn $116,586 in 2013 to have the same buying power. Now, that is using the official – AKA bogus – government-calculated inflation rate. I shudder to think what the real figure is. Jo and I spoke with several realtors who said housing prices had escalated since 2000, but the population mix had not changed. It is safe to conclude that a household with the 2013 median income now has about 74% of the buying power it did in 2000. This only confirms what I see and hear from our subscribers all over the world. Many folks – baby boomers and seniors in particular – are understandably frightened.Enough Money to Enjoy Time with Your Grandchildren The first question in any retirement calculation is: “How much do we need to retire?” I think of the answer as a two-part number. First, how much do we need to survive? Second, how much do we need to enjoy a comfortable lifestyle where we don’t stress out about money, can visit our grandchildren, and can even do some fun stuff with them? Last summer we took two of our grandchildren to a Cubs game, and the tickets alone were $150 for the four of us. That does not include transportation, hot dogs, drinks, and souvenirs for the kids. While it was an unforgettable day, it was expensive. Even taking grandchildren to the movies and buying popcorn puts a dent in a lot of retirees’ budgets. It’s quite sad to hear stories about young grandchildren asking Grandma and Grandpa to take them on a trip or visit on their birthday, and the answer is “no” because of financial worries. Many folks who were positive they had enough money to retire comfortably have had to adjust their lifestyles. Too many retirees have simply had to hunker down into survival mode.Investing from the Inside Out I don’t want to spend too much time on the politics that affect retirement issues. However, we should all let our elected representatives know how we feel. Most of us worked hard, played by the rules, and saved our money. Our Social Security benefits should not be reduced or taken away because our government can’t rein in its reckless spending. While we do not have direct control over Congress, we can control how we manage our life savings. There is no way to sugarcoat the fact that it takes work. We all have to manage and invest our life savings wisely, or risk losing it along with our retirement dreams. While many folks have already cut expenses and are looking for alternative sources of income, some are still overlooking the best investment they can make: investing in themselves. That means not blindly throwing money into a “black box” mutual fund; we have to actually learn about our investments now. Don’t let the process intimidate you. The education and skills that allowed us to build our nest eggs will also help us make it last. Learning about our investments is no different from learning about the thousands of other things we already know; we just need to put in the time, energy, and resources. Stockbrokers have been feeding us a line for too many years. They don’t have secret information or some sort of magic formula. The only magic formula is education and hard work.The Money Forever Plan Our subscribers have voiced their needs loud and clear. Every day more folks are taking the time to invest in themselves. They are no longer blindly investing their nest eggs. They want more than just another newsletter that gives stock tips; they want to know how to manage a retirement portfolio over the long haul. Our subscribers want the most out of retirement, and we work alongside them to make sure they get it. The folks who are thriving during retirement are the ones who have stepped up and embraced the learning curve. “Set it and forget it” is now a surefire way for our retirement dreams go up in smoke. In the April issue of Miller’sMoney Forever, we looked at portfolio allocation and the nuances of diversified investing. We took an in-depth look at why we had recommended certain investments, where they fit in our portfolio, and what percentage of our portfolio each pick should represent. The Money Forever portfolio is diversified, safe, and full of income-producing investments, but that’s just the starting point. We also walk you through how to incorporate our recommendations and tactics into your existing portfolio. Just a few minutes each day spent learning how to invest your money wisely can provide a huge return on our time and money. Many subscribers have been kind enough to send us testimonials outlining how well they have done with some of our picks. Every hour they invest in educating themselves pays dividends (pun intended). The solution is so simple that it baffles me why more folks don’t catch on. Once you educate yourself, you have the skills and confidence to make your own investment decisions. You never again have to wonder if the real reason your stockbroker called you about a hot stock was to generate a commission. Instead, each investment decision you make will be based on sound logic. I’d like to thank our readers for their feedback and suggestions. You’ve made it clear that, in addition to some doggone good stock recommendations, you also want an education on how to retire successfully. So please, keep the emails coming. The more you share concepts or products you want us to explain or focus on, the better job we can do for you. I am one of you, a retiree who came to Casey Research looking for answers. When we recommend a stock, we invest right along with you, but only after our requisite, companywide waiting period has elapsed. Seniors and savers, we are all in this together. I spent most of my career teaching adults, and I know that complicated information can be taught in simple, easy-to-follow ways. I don’t know about you, but geek talk just frustrates me. That’s why we explain money matters in plain English, so there’s no need to get a Ph.D. in economics or keep an investment dictionary handy when you subscribe. I’m sure we have all told our children and grandchildren that an education is one thing that can never be taken away. In our case, a financial education can keep us independent and in the game (and, if we want, we can take the grandchildren along). The current the price of a subscription is affordable – less than that of a typical morning newspaper. The best part is you can take advantage of our 90-day, no-risk offer. You can cancel for any reason, no questions asked, within the first 90 days. As you might expect, our cancellation rates are very low, and we aim to keep it that way.On the Lighter Side For those who are fans of the Hostess Twinkie, they should be back in grocery stores sometime late this summer. I have never been a Twinkie lover, but I have never been unable to eat just one Ho-Ho in a package of two. My wife Jo tells me they come two to a package so they can be shared. Yeah, right! I buy two packages, and we can share that way. We are now back in Illinois for the summer, where I grew up. A friend recently said something to the effect that I was “going home for the summer.” I had to stop for a moment as I realized I no longer look at it as home. It has gone through so many changes in my 73 years that it is more like a place where I have fond memories. It’s just not the simple, easy life like it was when I was growing up. And finally… I have mentioned our friend Toots many times, who was a high school classmate of mine. She was younger, and graduated at 17 among the top five in our class. I like to remind her that it was folks like me who helped make the upper half of the class possible. We made the mistake of making fun of her because of her young age, as she had to wait a year longer to get her driver’s license. She is now getting her revenge. Knowing I had a birthday recently, she sent me some bumper stickers reminding me that I was one of the older folks in our class.last_img read more

4 Aces releases Aqua swirl paper cup for water coolers

first_img4 Aces releases Aqua swirl paper cup for water coolersPosted By: News Deskon: November 09, 2018In: Beverage, Industries, Refreshment, VendingPrintEmailUK-based disposable cup supplier 4 Aces has launched a new paper cup aimed at the water industry as an alternative to plastic cups.Suitable for water coolers and dispensers, the 7 oz cold cups feature a new, blue and white Aqua swirl design, which 4 Aces says will appeal to clients who want their offering to stand out to consumers.This Aqua swirl design is inspired by the red and gold swirl featured on the hot beverage cups that 4 Aces supplies to the vending industry, which have proven popular with clients in the industry thanks to its premium feel and trouble-free vend.David Blake, sales director of 4 Aces said: “This is one of our company’s signature designs and so was a natural choice to carry across as a paper alternative to plastic cold cups.“We’ve altered the colours to reflect the likely contents that the cup will carry and are hoping that our water customers will embrace this new offering.”Share with your network: Tags: 4 Acespaper cupsvendinglast_img read more

Pureport Announces Feature Enhancements to Its OnDemand Cloud Connectivity Platform

first_imgNewFunctionality Includes Cloud Grade NAT for IP Address Conflict ResolutionMulticloud Networking Provider Pureport announced major feature enhancements to its Multicloud Fabric platform which enables seamless orchestration of private connectivity to the major cloud providers. Pureport’s Multicloud Fabric empowers businesses of all sizes to securely interconnect clouds, sites, and on-premises facilities in minutes, without the need for additional physical infrastructure.Multicloud, hybrid cloud, and multi-site networks are often configured with overlapping IP address ranges. To solve this common obstacle, Pureport’s new product enhancements include Cloud Grade NAT functionality, a feature that intelligently detects and resolves overlapping IP address conflicts. By mitigating these conflicts, organizations can avoid significant expense, and immediately proceed with network interconnection.“Enabling the new Cloud Grade NAT functionality for a connected network is as simple as checking a box in our console, which is just one example of how these features are truly evolving the way cloud networks are built,” said Doug Mittendorf, CTO of Pureport. “A great application of the Cloud Grade NAT functionality is to support SaaS providers who offer private connectivity to their customers, where the SaaS provider has no control over the customer networks. With Cloud Grade NAT, this is no longer an issue.”Marketing Technology News: Airtame Adds Power over Ethernet Product to Their ServicesIn this latest release, Pureport’s Console has been enhanced to make it even easier to build and deploy multicloud, hybrid cloud, and multi-site networks within minutes. The Console now offers a user-friendly, visual tool to manage cloud networks, thereby reducing the administrative overhead and technical expertise often required when deploying traditional networks.“Cloud networking is becoming more and more challenging as organizations attempt to marry multiple dispersed technologies, and we’re on a mission to remove the common obstacles organizations face today when creating and managing cloud networks—specifically time to deployment, and excessive expenses incurred in deployment and management,” said Rich Lee, CEO of Pureport. “This latest version of Pureport’s platform addresses industry feedback and makes cloud networking easier, faster, and more affordable.”Marketing Technology News: Jumio, Monzo Partnership Grows to New HeightsAdditional Key Feature Enhancements of Pureport’s Multicloud Fabric include:Layer 3 Networking – All Pureport gateways now support BGP Peering to allow for dynamic exchange of routes with edge routers, as well as between other gateways across an organization’s private network. Cloud connections support automatic failover between redundant gateways and allow all edge routers to dynamically learn the routes to all interconnected subnets.Automated BGP Configuration – Pureport’s Distributed Multicloud Router simplifies network configuration and deployment by assigning network subnets, discovering autonomous system numbers, and automatically configuring BGP sessions on the administrator’s behalf.High Availability – Every connection within a Pureport network is highly available by default, where each connection has two gateway containers across separate availability zones. Traffic will continue to flow, even if a failure—such as a power outage, provider circuit loss, switch failure, engine failure, etc.—occurs in one of the two zones.Power Seamless Integrations with Existing Orchestration and Automation Systems –Pureport now exposes a simple REST API, allowing for DevOps automation of multicloud and hybrid cloud networks using existing orchestration and automation tools.Expanded RegionsPureport’s Multicloud Fabric is deployed to five key interconnection facilities (San Jose, Seattle, Washington DC, Chicago, and Dallas) with a full-mesh backbone between all locations. This allows for low-latency, private connectivity between all public cloud regions in the US.Marketing Technology News: Cheetah Digital Strengthens EMEA Team With Three Executive Additions Pureport Announces Feature Enhancements to Its On-Demand Cloud Connectivity Platform PRNewswireMay 8, 2019, 8:04 pmMay 8, 2019 Marketing TechnologyMulticloud Fabric platformMulticloud NetworkingNewsphysical infrastructurePureportRich Lee Previous ArticleAudio Visual Solutions Company, IVCi, Explains How Companies Can Leverage Video Walls to Increase Room FunctionalityNext ArticleLinda Avery, Chief Data Officer at the Federal Reserve Bank of New York, Named US Chief Data Officer of the Year 2019 by CDO Clublast_img read more

Immunotherapy increases survival in some patients with metastatic triple negative breast cancer

first_img Source: Reviewed by James Ives, M.Psych. (Editor)Oct 22 2018Immunotherapy improves survival in some patients with metastatic triple negative breast cancer, according to late-breaking results from the IMpassion130 trial reported at the ESMO 2018 Congress in Munich.Prof. Peter Schmid, first author, said the results “will change the way triple-negative breast cancer is treated”. “Atezolizumab in combination with nab-paclitaxel is the first targeted treatment to improve survival in metastatic triple negative breast cancer,” said Schmid, Clinical Director of London’s St. Bartholomew’s Breast Cancer Centre, Barts Health NHS Trust, UK and lead of the Centre for Experimental Cancer Medicine, Barts Cancer Institute, Queen Mary University of London, UK. “It is also the first immune therapy to improve outcome in this cancer. Most of the survival benefit was in patients with PD-L1 positive tumors.”Triple negative breast cancer is the most aggressive type of breast cancer. It is relatively rare and often affects younger women. Once the disease becomes metastatic, the median survival is around 12 to 15 months. Triple negative breast cancer does not have receptors for the hormones oestrogen or the protein HER2, meaning it cannot be treated with hormone therapy or drugs targeting HER2. The main drug treatment is chemotherapy and most patients develop resistance to chemotherapy within a few months.The phase III IMpassion 130 trial enrolled 902 patients with metastatic triple negative breast cancer who had not received prior treatment for metastatic disease. Patients were randomly allocated to standard chemotherapy (nab-paclitaxel) plus atezolizumab, an antibody targeting the protein PD-L1, or to standard chemotherapy plus placebo. The two main objectives were to see whether the drug combination could slow cancer growth (progression-free survival) and prolong life (overall survival) in all patients and in those expressing PD-L1. The median follow-up was 12.9 months.The combination therapy reduced the risk of disease worsening or death by 20% in all patients and 38% in the subgroup expressing PD-L1. In the entire study population, the median progression free survival was 7.2 months with the combination and 5.5 months with chemotherapy alone, with a hazard ratio (HR) of 0.80 (p=0.0025). In the PD-L1 positive group, the median progression free survival was 7.5 months with the combination and 5.0 months with chemotherapy alone (HR 0.62, p<0.0001).More than half of patients were alive at the time of analysis, so this was an interim assessment of overall survival. In patients with PD-L1 positive tumors, the median overall survival was 25.0 months with the combination compared to 15.5 months with standard chemotherapy alone (HR 0.62). In all patients, survival was 21.3 months with the combination versus 17.6 months with chemotherapy alone which was not statistically different, likely because of the short follow-up.Related StoriesStudy reveals link between inflammatory diet and colorectal cancer riskSpecial blood test may predict relapse risk for breast cancer patientsSugary drinks linked to cancer finds studyThe proportion of patients responding to treatment (objective response rate) was higher with the combination compared to chemotherapy alone for all patients (56% versus 46%) and those with PD-L1 positive tumors (59% versus 43%).Schmid said the combination therapy was well tolerated. Most side effects were due to chemotherapy and occurred at a similar rate in both treatment groups, although there was a minor increase in nausea and cough in the combination group. Side effects related to immune therapy were rare, the most common being hypothyroidism which occurred in 17.3% of patients receiving the drug combination and 4.3% receiving chemotherapy alone.Schmid said: "Immune therapy on top of standard chemotherapy prolonged survival by ten months in patients with tumors expressing PD-L1. This combination should become a new treatment option for patients with metastatic triple negative breast cancer."Commenting on the results for ESMO, Dr Marleen Kok, Medical Oncologist, The Netherlands Cancer Institute, Amsterdam, said: "This is the first randomized phase III trial providing evidence that adding immune therapy to standard chemotherapy increases progression-free survival in metastatic triple negative breast cancer, particularly in patients with PD-L1 positive tumours, and extends overall survival in the PD-L1 positive subgroup. While the benefit in terms of progression-free survival was relatively small, around three months, the gain in overall survival in the PD-L1 positive subgroup was impressive with a ten-month benefit. Around 40% of the tumours were PD-L1 positive. The IMpassion 130 data will probably change the treatment landscape for our metastatic triple negative breast cancer patients."Kok noted that it is still not clear what the best chemotherapy backbone is for anti-PD-(L)1 treatment and that many trials are ongoing, evaluating the additional effect of anti-PD-(L)1 on top of chemotherapy in metastatic breast cancer but also for early breast cancer patients. "This should help answer the question of which chemotherapy backbone is most effective in combination with anti-PD-(L)1." she said. "We also need more studies to determine a biomarker for selecting patients most likely to benefit from this treatment."last_img read more

New analysis methods facilitate the evaluation of complex engineering data

first_imgFor less noise: high-resolution simulation of flows in a car air conditioning system. Credit: Fraunhofer SCAI This document is subject to copyright. Apart from any fair dealing for the purpose of private study or research, no part may be reproduced without the written permission. The content is provided for information purposes only. Provided by Fraunhofer-Gesellschaft A further increase in the performance of supercomputers is expected over the next few years. So-called exascale computers will be able to deliver more precise simulations. This leads to considerably more data. Fraunhofer SCAI develops efficient data analysis methods for this purpose, which provide the engineer with detailed insights into the complex technical contexts. Using machine learning for the early detection of anomalies helps to avoid damagecenter_img Citation: New analysis methods facilitate the evaluation of complex engineering data (2019, January 30) retrieved 17 July 2019 from Explore further Simulations on supercomputers answer important industrial questions, such as how air flows behave in air conditioning systems, on rotor blades or for entire airplanes. In the coming years, new approaches to hardware design will make computers available which have a capacity of one trillion computing operations per second. So-called exascale computers have a computing speed a thousand times higher than previous supercomputers. This enables them to overcome complex problems that are not yet solvable. In addition, they deliver more accurate results and thus more economical solutions for industrial tasks. However, exascale simulations also generate significantly larger amounts of data. This creates new challenges in data analysis.Scientists at the Fraunhofer Institute for Algorithms and Scientific Computing SCAI have addressed this problem. They develop methods which perform data analysis during simulation. This approach minimizes memory requirements and computing time. In this way, even huge amounts of data can be analyzed efficiently. The SCAI scientists concentrate on methods for the comparative analysis of simulation data. For example, the comparison of the data enables engineers to see at a glance how a modified component shape affects the flow behaviour inside an air conditioning system and thus the aerodynamic noise generation level. Eventually, that will help to design better products.As a member of the newly founded “Competence Center of the European Union for Engineering Applications” EXCELLERAT, Fraunhofer SCAI works together with 13 partners from 7 European countries. The aim is to make the best possible use of the new potentials of supercomputing and thus strengthen Europe’s competitiveness in this field. Over the next three years, the participants will deal with six selected program codes and associated workflows, such as data analysis, management and visualization. In addition to the efficient handling of large amounts of data, the project focuses on the scalability of the codes. In this context, scalability means that programs work efficiently on both laptops and exascale computers. Since EXCELLERAT should also help to expand the use of supercomputing in industrial contexts, the project team will optimize the codes using twelve application examples from industry. Among others, these include the simulation of flows in car air conditioning systems as well as the calculation of combustion chamber emissions. Moreover, a common knowledge platform is to be developed.last_img read more

Datadriven modeling and AIbased image processing to improve production

first_img Interactive control to guide industrial robots Realtime Pose Estimation. Credit: Fraunhofer FIT Automation and the development of business processes require data that inform the optimization of processes or the development of innovations. At Hannover Messe 2019, Fraunhofer FIT will present a platform technology that integrates smart databases, specific analysis methods as well as networked sensors and measuring instruments. Functionalities such as maintenance and operations are represented in the data models and may be enhanced to include predictive maintenance. This facilitates agile development of new services and business models and their flexible adaptation to rapidly changing customer needs.”It is important to understand that – in contrast to traditional production and automation technologies with their highly customized but inflexible models – with data-driven models we’re no longer looking for absolute results. The models take into account that data acquisition and data quality can be adapted to situational requirements, to be able to react more flexibly”, explains Prof. Dr. Harald Mathis, leader of the Biomolecular Optical Systems group at the Fraunhofer Institute for Applied Information Technology FIT, who also heads the SYMILA Fraunhofer Application Center at Hamm. At Hannover Messe 2019, Fraunhofer FIT will present data-driven modeling supporting production planning and optimizing resource utilization. The models help to understand and optimize complex processes, and can be used as predictive tools. In addition, we demo a system that uses AI-based image processing to monitor and evaluate, in real time, the situation and behavior of people, e.g. in a production setting. The system may be used, for instance, to automatically raise the alarm if a person is sitting or lying on the floor, indicating a dangerous situation. Meet us in hall 2, booth C22. Citation: Data-driven modeling and AI-based image processing to improve production (2019, March 7) retrieved 17 July 2019 from Explore furthercenter_img Provided by Fraunhofer-Institut fuer Angewandte Informationstechnik (FIT) Another important component of our system is what we call Smart Data Exchange. It guarantees a maximum of data security and data integrity, e.g. if data must be transferred from one production site to another.Recognition of the postures of humans in their work environment using AI-based image analysis Our second exhibit is a smart video system to protect workers in hazardous work environments. The system is capable of detecting the basic anatomical structure of humans, i.e. head, rump, arms and legs, in a live video stream. The method used is called Realtime Pose Estimation. Based on the detected anatomical structures and their orientations, additional neural networks determine the postures of the detected figures, e.g. if a person is standing, sitting or lying on the floor in the area under surveillance.Realtime Pose Estimation is an AI application. The algorithms broadly mimic neural processes in the brain, simulating a deep network of nerve cells. Analogous to the human model, these neurons learn from experience and training. We used the COCO dataset, which contains some 250,000 images of persons with their body parts identified and annotated, and several further datasets to train our system. It can now reliably identify body parts in unfamiliar scenes in live video streams. Recognition of the postures of humans using AI-based image analysis. Credit: Fraunhofer FIT This document is subject to copyright. Apart from any fair dealing for the purpose of private study or research, no part may be reproduced without the written permission. The content is provided for information purposes only.last_img read more