Media Release – Cavendish Road SHS

first_imgStudents at the school study touch football as a subject and the results are outstanding. The girls are especially successful and they are the current World All Schools Champions having first won the title in Singapore in 2006 and then successfully defending their title again in 2008. Last year the under 15 girls won the prestigious Qld All Schools title from almost three hundred competing schools.The school contributed no less than three girls to the successful Australian under18 team, which won the Trans Tasman series in Auckland last year.In July of this year the under15 girls team have accepted an invitation to travel to Bristol, UK to compete in the European Championships where they will play in the Open Women’s division against teams including England, Scotland, Wales and France. This in itself will provide a very real test for the young Cavendish Road students.The school team has a number of talented indigenous students including Qld representative and team captain Tracy Hill, who it is hoped, will one day emulate Bo Dela Cruz the Australian Women’s indigenous superstar.The girls are coached by former Australian Women’s team, triple World Cup winning coach, Peter Bell. Mr Bell, a PE teacher at the school and coordinator of the touch excellence program says, “The girls have been training and fundraising for some time. They are really focussed and looking forward to the experience. While we are reasonably confident of doing well, this is more about contributing to the development of the sport of touch in Europe and importantly in schools in the UK.” The team will tour around Britain and France in a lead up to the Euros and will conduct clinics as well as play games in British schools. The cost of the tour is around $60000 and the team would be extremely appreciative of anyone who wishes to help the team financially with their fundraising efforts or otherwise. The school phone number is 07 3394 0773.Related Filesmedia_release_cav_road_cobras__2_-doclast_img read more

Time for federal parties to take action on privacy expert says

first_imgCavoukian wants to see the issue addressed in the October election campaign, and believes Canada should adopt a privacy-by-default policy.“People shouldn’t have to search through all the legalese and the terms of service and the privacy policy to find the opt-out box for privacy. They should get privacy automatically.”The commissioners’ report finds Facebook failed to have proper safeguards in place when more than 50-million users had their data harvested in the Cambridge Analytica controversy. Facebook denies it broke the law and says it has taken steps to better protect people’s information.“If you value your freedom, then you value privacy,” Cavoukian says. “We’ve got to stand up for that.”The report finds major shortcomings in the social media giant’s practices and highlights the need for legislative reform to protect Canadians.The complaint that prompted the probe followed reports that Facebook had let an outside organization use an app to access users’ personal information, and that some of the data was then shared with others, including Cambridge Analytica. OTTAWA (NEWS 1130) – A day after the federal and B.C. privacy commissioners declared Facebook broke Canada’s privacy laws, one expert is applauding the report and hopes federal parties make privacy a campaign issue this fall.“Facebook’s privacy framework is empty,” Privacy Expert Ann Cavoukian, a Senior Fellow of the Ted Rogers Leadership Centre at Ryerson University, says. “They’re not walking the talk. They do a lot of talking, making you believe that they have strong privacy in place, but they don’t.”She tells CityNews it’s about time privacy commissioners take action against Facebook, and she hopes the Trudeau government and Opposition parties take this seriously.Watch: Canadian privacy watchdog says Facebook broke the lawlast_img read more

Young goalies battle for time on field

Of the 26 players on the Ohio State men’s soccer team, 18 are freshmen or sophomores.At perhaps the most important position on the field, a pair of young players is competing for playing time.After six non-conference games, sophomore Ryan Dalton and redshirt freshman Matt Lampson have each started three games at goalie. Each has recorded one shutout, and each has received almost identical playing time.  Goalkeeper coach Taly Goode plans to play both men equally until there is a distinction between the two.  “There isn’t much separation between the two just yet,” Goode said. “We are looking for one to establish a good rhythm and consistency.” Through six games, Dalton has played 290 minutes, while Lampson has spent 310 minutes in goal.Ideally Goode would like to see a starter emerge, but maintains that their strengths lie in the same places, and they are playing on an even field.  “It’s not a bad situation to be in with such strength on such a young team,” Goode said.  When asked which player he sees rising to the top, Goode said that they are just about dead even.“Ryan has strong communication with the team and Matt has slightly better distribution,” Goode said.  The No. 24 ranked Buckeyes recently entered the Soccer America Poll for the first time this season.  The team’s record (3-0-3) shows they are off to a good start and deserve their spot in the top 25.  There is less pressure on the young team, and they anticipate catching their opponents off guard.  Lampson, a transfer from Northern Illinois, is taking Ohio State in stride. He began training with the Buckeyes last spring.  “I wanted to be part of a better program that is more renowned and successful,” Lampson said, addressing the reason behind his transfer. “Coach Bluem was happy to have me working with the Buckeyes.”Both players recognize what a fantastic soccer program Ohio State has maintained and are proud to be a part of the fight to the top.The undefeated Buckeyes face IUPUI at Jesse Owens Memorial Stadium at 7 tonight. read more

Gallery Ohio State Wrestling vs NC State

#2 Joey McKenna attempts to finish a single leg takedown on North Carolina State University’s Jamal Morris in the 141-pound bout of the Ohio State vs. NCSU dual meet at St. John Arena. McKenna won the bout by major decision, 10-2. Credit: Sal Marandino | For The Lantern The Ohio State Wrestling team took on North Carolina State on Jan. 6. in St. John Arena and won 26-10. The Buckeyes improved their record to 5-0. Photos by Sal Marandino.

2020 Kia Soul priced starts at 18485

first_img 2.0L I4 GT-Line IVT 32 Photos $21,285 2020 Hyundai Palisade review: Posh enough to make Genesis jealous Trim 2.0L I4 2020 Kia Telluride review: Kia’s new SUV has big style and bigger value LX 6MT The GT-Line can also be upgraded with an optional 201 horsepower, 1.6-liter turbocharged four-cylinder engine and seven-speed dual-clutch transmission for $28,485. This top-trim model is fully loaded with all of the bells and whistles in the Soul’s new bag of tricks, including a sport-tuned suspension and brakes, Kia’s enhanced DriveWise safety suite, a massive 10.3-inch infotainment system, head-up display and more. At only about $500 more than a loaded 2019 Soul Exclaim Turbo with significantly more features and content, the line-topping 2020 GT-Line 1.6T looks like an even better deal than the lower trim levels.The 2020 Kia Soul should start arriving in US dealerships over the coming weeks, where it will compete nicely with the likes of the Nissan Kicks ($19,585), Toyota C-HR ($22,090) and Honda’s HR-V ($21,565). S IVT $19,985 2020 Kia Soul pricing Kia $28,485 $23,685 $22,485 Kia has also ditched the weird punctuation based naming convention (Soul, Soul+, and Soul!) in favor of more easily understandable LX, S and EX trim levels to indicate base, mid and upper tiers. The 2020 lineup also includes the new X-Line ($22,485) and GT-Line ($21,285) styling packages, which tweak the Soul’s updated design for a more rugged or sporty appearance, respectively. 2.0L I4 2.0L I4 Engine The 2020 Kia Soul and Soul EV make their world debut at the LA Auto Show 2.0L I4 SUVs Wagons Crossovers Hatchbacks $18,485 Price (including $995 destination) EX IVT Share your voice X-Line IVT Kia has finally slapped a price tag on its 2020 Kia Soul. The boxy, subcompact crossover will start at $18,485 (including a $995 destination charge) for the base LX model with the six-speed manual transmission, a price hike of about $1,000 over last year. For the extra dough, the new Soul rolls out with more standard features and optional equipment and improved utility, thanks to even more cargo space than before. The base LX is the only Soul trim available with that six-speed manual gearbox; most trim levels of this new generation will mate their 147 horsepower, 2.0-liter four-cylinder engines with a new Intelligent Variable Transmission — Kia’s version of a continuously variable transmission — which promises smoother operation and improved fuel economy over the old conventional six-speed automatic. Pricing for these IVT-equipped models ranges between the $19,985 LX IVT and and the more fully equipped EX IVT for $23,685. 1.6L turbo I4 2020 BMW M340i review: A dash of M makes everything better $21,285 Post a comment 2.0L I4 0 More From Roadshow Tags LX IVT GT-Line 7DCT Kialast_img read more

After monopoly ruling Qualcomm asks to delay reforms citing US place in

first_img See All Aug 31 • iPhone 11, Apple Watch 5 and more: The final rumors reading • Qualcomm asks appeals court to delay contract renegotiations because of 5G Share your voice See also Aug 31 • Your phone screen is gross. Here’s how to clean it “Qualcomm’s licensing practices have strangled competition in the CDMA and premium LTE modem chip markets for years, and harmed rivals, OEMs, and end consumers in the process,” Koh wrote in her ruling in May.The ruling came as a surprise to Qualcomm and others in the mobile market. For Qualcomm, the verdict called into question the company’s entire business model. While it sells processors that connect devices to mobile networks, it also generates a significant percentage of its revenue from licensing. If it can’t collect royalties based on the value of a handset — which it had done in the past — it will generate less money and may have to rethink its model entirely. Even though it’s appealing the ruling, Qualcomm’s licensees likely will try to alter their contracts.Koh, in her ruling, said Qualcomm can’t force a customer to sign a license before it’ll supply that company with chips. It “must negotiate or renegotiate license terms with customers in good faith under conditions free from the threat of lack of access to or discriminatory provision of modem chip supply or associated technical support or access to software.”Following the ruling, Qualcomm said it would seek a stay of the district court’s judgment and an expedited appeal to the Court of Appeals. The decision is now in the appeals court’s hands.Though Qualcomm likely won’t have to renegotiate its new agreement with Apple — the two settled their long-running licensing and patent disputes during opening arguments in a May trial — it’ll have to offer other customers the chance to change their terms.The company in a filing Monday said that there’s “good cause” to expedite its appeal. And the FTC consented to Qualcomm’s request for a faster process, Qualcomm said. “As described at length in Qualcomm’s contemporaneously filed motion for partial stay, Qualcomm will suffer irreparable harm from the injunction as it stands, necessitating prompt resolution of the appeal,” the company said.  Apple Powerful chipmaker Qualcomm is just too powerful, judge… Qualcomm 5G 4G LTE Apple FTC 1:48 Tagscenter_img 0 Now playing: Watch this: Aug 31 • Verizon vs AT&T vs T-Mobile vs Sprint: Choose the best 5G carrier Judge denies Qualcomm’s bid to delay contract renegotiations Qualcomm is a monopoly and must renegotiate deals, judge rules Qualcomm-FTC lawsuit: Everything you need to know Apple and Qualcomm settle: Here’s what it means for your next iPhone Qualcomm also invoked the global race to 5G and the US’ priority to lead when it comes to the super fast, next-generation technology. “Unless stayed, the injunction will significantly impair an American company that is the worldwide leader in the development of cellular technologies, at a critical moment in the development of the worldwide standards for next-generation 5G cellular systems, thereby forfeiting the lead to foreign interests,” Qualcomm’s filing said. The company said firms are already are trying to renegotiate their contracts with Qualcomm and noted it “will be forced to negotiate under the cloud of an injunction requiring it to accept terms to which it would not otherwise agree.”The appeals court filings come days after US District Court Judge Lucy Koh denied Qualcomm’s request to delay carrying out remedies she ordered after Qualcomm lost an antitrust case and was found to be a monopoly in wireless chips. The reforms included renegotiating licensing agreements previously reached with handset makers like LG and submitting to monitoring by the Federal Trade Commission. Qualcomm wanted the injunctions to be put on hold while the case made its way through the appeals process. Instead, Koh, in a ruling filed last week in the court’s Northern District of California, said she denied Qualcomm’s motion for a stay pending appeal after reviewing the motion, amicus briefs filed in opposition to Qualcomm by LG and others, arguments and evidence from the trial and other documents relevant to the case. Monopoly battleTwo years ago, the FTC accused Qualcomm of operating a monopoly in wireless chips. The FTC said Qualcomm forced customers like Apple to work exclusively with it and charged “excessive” licensing fees for its technology, in part by wielding a “no license, no chips” policy. Qualcomm’s practices prevented rivals from entering the market, drove up the cost of phones and in turn hurt consumers, who faced higher handset prices, the FTC said.Qualcomm argued the FTC’s lawsuit was based on “flawed legal theory” and that customers choose its chips because they’re the best. It also argued that competition is fierce in the mobile chip market and that Qualcomm never stopped providing processors to customers, even when they’d been arguing over licenses.The parties faced off in an 11-day trial in January. In May, Koh ruled in the FTC’s favor, saying Qualcomm was a monopoly that illegally hurt competitors in the wireless chip market. The ruling, which came four months after the trial ended, said Qualcomm must change how it does business and renegotiate license deals with its customers. To hold the company accountable, the court said Qualcomm must also submit compliance and monitoring reports for the next seven years and report to the FTC on an annual basis. • Post a comment Aug 31 • iPhone XR vs. iPhone 8 Plus: Which iPhone should you buy? Mobile Components Tech Industry Phones In a January trial, UC Berkeley economics professor Carl Shapiro testified on behalf of the Federal Trade Commission that Qualcomm hurt competition. Judge Lucy Koh ruled in the FTC’s favor, and Qualcomm is appealing. Vicki Behringer Until its appeal is heard, Qualcomm has asked for a delay to reforms ordered by a district court, including the requirement that the chipmaker must renegotiate licensing deals with phone makers. And it’s using the 5G race to help justify a reprieve. The company on Monday filed a motion with the US Appeals Court for the Ninth Circuit, asking the court to grant a stay because carrying out the actions would “fundamentally change the way it has done business for decades.” If the appeals court ultimately finds in Qualcomm’s favor, the chip giant said, the company won’t be able to undo the changes it’s made. Qualcomm also filed a request for an expedited briefing and hearing for the appeal. “This court has repeatedly found that a stay is warranted when — as here — an injunction imposes changes on a party’s business practices and commercial arrangements that cannot be undone by this court’s later reversal of the district court’s judgment,” Qualcomm said in its filing requesting the stay. “There is no basis to depart from that settled, sound practice.”last_img read more

What You Need To Know About A Mueller Subpoena Trump And The

first_img Share Chip Somodevilla/Getty ImagesPresident Trump’s legal team appears divided over whether to grant an interview with special counsel Robert Mueller or whether to resist.Updated at 11:35 a.m. EDTThe slow-motion showdown between President Trump and Justice Department special counsel Robert Mueller has entered a new phase: a knife fight over how, when or whether the two men may meet for an interview.Direct interaction between the president and the special counsel’s office has been possible all along, and in an earlier phase, Trump said he wanted to talk with Mueller — if his lawyers said it was OK.Now, however, as actual potential questions are being aired and talk of potential subpoenas is bandied about, the president is less enthusiastic.Here’s what you need to know about the state of play.Can the Justice Department subpoena the president?Yes — but it would be hardball. If Trump did not agree to an interview that complied with what Mueller’s team wanted, the special counsel’s office could try to compel Trump to appear before a grand jury, something that has never happened before.In 1998, Justice Department independent counsel Ken Starr issued a subpoena to force President Bill Clinton to answer his questions. Clinton’s legal team responded by agreeing to an interview in which the president’s lawyers could be present and he could appear before the grand jury via video — and Starr withdrew the subpoena.Could Trump resist a subpoena?Ultimately no, legal experts have said, but it might take a long battle in court to get there. How long? No one knows — a subpoena from Mueller that Trump fought would be a novel legal problem and might require months of arguments or rulings.Could Trump invoke his Fifth Amendment rights?Of course — the Constitution protects his right not to give evidence that would require he incriminate himself.That’s the choice Trump’s longtime attorney, Michael Cohen, made last month in responding to a federal lawsuit by the porn actress Stormy Daniels, who wants to escape the nondisclosure agreement she signed with Cohen and Trump. Cohen said he wouldn’t give evidence in that proceeding because he also is dealing with a federal criminal investigation into his business practices in New York and battling prosecutors over evidence in that case. So a federal judge agreed to pause Daniels’ lawsuit until this summer.But there’s a political dimension here as well. Trump has criticized people who invoke their Fifth Amendment rights. “The mob takes the Fifth,” as he has said. “If you’re innocent, why are you taking the Fifth Amendment?”So although Trump has the option not to give evidence, the question for him and his political team would be whether they wanted to live with the commentary that would invite from opponents.Why wouldn’t Trump just cooperate to prevent a subpoena or taking the Fifth?The president and his legal team stress that they have been. And Trump has said several times how much he wants to talk with Mueller, if his lawyers counsel him to do so.But Trump’s freewheeling speaking style is well-known both to his critics and his supporters, including his lawyers. He has been described as someone who likes to digress, to prevaricate, to exaggerate. And if he were to do that in an interview with Mueller, that could create legal problems.Mueller has already concluded a number of guilty pleas — including with former national security adviser Mike Flynn, campaign adviser George Papadopoulos — in which people admitted lying to the FBI.That doesn’t mean Trump would lie or that if he did lie, he might be indicted (the question about whether the Justice Department could indict a president is disputed) but, as with the Fifth Amendment question, the political blowback could be serious.What do Trump’s lawyers say?The president’s advisers appear to be split on a Mueller interview. Some of them, and some outside advisers, including Roger Stone, say Trump must not talk with Mueller.Others, including one of Trump’s newest lawyers, former New York City Mayor Rudy Giuliani, appear to want to keep the door open to an interview. That would enable Trump to placate the special counsel short of a subpoena and also permit the White House to continue touting its cooperation with the investigation. These two camps are now warring in the press.The don’t-do-an-interview camp may have been the origin of an account of the questions Mueller has told Trump’s lawyers he wants to ask — seeking to illustrate the breadth and detail that Trump would need to cover and the potential pitfalls that could create.And the do-an-interview camp may have responded on Tuesday with a riposte that made clear Mueller has already dropped the s-bomb — “subpoena” — in his discussions with Trump’s legal team.The two sides are battling to shape the public discussion about the president’s legal dilemma and grab the attention of the principal himself. Trump’s latest thinking appears to be that he is cold to the idea of an interview and he considers the Justice Department investigation to be nothing but a “witch hunt.”Could Trump solve his problems by firing Mueller?The White House says it believes Trump enjoys the privilege to fire Mueller, but that he has no intention of doing so. Trump’s allies in Congress, led by House Speaker Paul Ryan, say they’ve received assurances from the White House that Mueller’s dismissal is not in the offing.The latest target by Trump and his supporters, however, isn’t Mueller, but the man to whom he reports: Deputy Attorney General Rod Rosenstein.The president and his allies have been sandblasting the Justice Department for months over what they call “bias” and officials’ abuse of their power, and this week some members of Congress surfaced “articles of impeachment” on which lawmakers could vote to remove Rosenstein.Trump and his allies complain that Rosenstein and the Justice Department have been slow-walking their requests for documents about the Mueller investigation and other matters, part of what conservatives call a conspiracy to frame Trump.The president renewed his complaints on Wednesday in a post on Twitter that held open the possibility he might use “the powers granted to the presidency” and “get involved!”Rosenstein says the Justice Department wants to cooperate with members of Congress but within reason. He said on Tuesday that “articles of impeachment” and other such tactics wouldn’t intimidate him.“There have been people who have been making threats privately and publicly against me for quite some time and I think they should understand by now the Department of Justice is not going to be extorted,” he said.Copyright 2018 NPR. To see more, visit read more

DC School Chancellor Unveils 5 Million Program to Boost Student Approval of

first_imgDistrict of Columbia Public Schools (DCPS) Chancellor Kaya Henderson confirmed her commitment to increasing student satisfaction Feb. 25 with the announcement of a $5 million award to be used toward that end for the 2014-2015 school year. “With this new award, we will help our schools meet the needs of our students beyond the classroom,” she said in a telephone conference call with reporters. “I’m a DCPS parent. And for me, I want my two boys not just to do well on their tests. I want them to thrive. I want them to love going to school, and feel great about their school.” Increasing student satisfaction to at least 90 percent of the student body is one of Henderson’s top priorities, as outlined in the strategic plan for DCPS, “A Capital Commitment,” and a top concern of parents, teachers, principals and other stakeholders. School officials characterize the $5 million student satisfaction initiative to come from the budget for the upcoming year as an extension of “Proving What’s Possible,” a $10 million grant program launched in 2012 that gave money to 59 schools to experiment with an extended day, new technology and teacher training, all geared to increasing student satisfaction. According to a survey administered to 20,000 DCPS students in grades three through 12 last year, about 74 percent of Black students said they like their school, compared to 92 percent of White students. To increase those numbers, each of the system’s 111 schools can apply for a grant under the new initiative to invest in field trips, extracurricular activities, clubs, new athletic teams, anti-bullying initiatives and other areas. Schools can apply immediately. The amount of the award will be based proportionally on student enrollment. Final applications are due the week of March 5; the award winners will be announced during the week beginning March 10. “I firmly believe these awards will help put our schools on even stronger footing,” Henderson said. According to DCPS spokeswoman Melissa Salmanowitz, funding for the program will come through the budgeting process. “The chancellor will make this a priority for the budget when she receives our budget mark from the mayor,” she explained. D.C. Mayor Vincent Gray has already expressed his support for the program. “Our schools should be places that make our students feel excited and supported,” he said in a statement. “This new award is a great step in the right direction to help improve student satisfaction and ultimately improve our schools,” he added.last_img read more

Network18 slips to sharp Rs 27cr quarterly loss

first_imgNetwork18 Media and Investments on Wednesday reported a consolidated net loss of Rs 27.42 crore for the second quarter ended September 30. The company had registered a consolidated net loss of Rs 36.46 crore in the same period a year ago. Network18’s total income from operations for this quarter stood at Rs 795.1 crore. It was Rs 736.12 crore during the same period of the previous fiscal.last_img

October 30 2017 Journalist Daniel Oberhaus visite

first_imgOctober 30, 2017Journalist Daniel Oberhaus visited Arcosanti in preparation for his eloquent article featured on Vice’s Motherboard. The essay is definitely worth the read and its already stirred up excitement from visitors.Read it here!last_img

Qualified Forest Program bills signed into law

first_imgOn hand for the ceremony were from left: Jamie Clover Adams, Michigan Department of Agriculture and Rural Development director; McBroom; Sen. John Moolenaar; Gov. Rick Snyder; Rep. Frank Foster; Sen. Darwin Booher, Rep. Bruce Rendon; and Sen. Tom Casperson.Legislation to encourage owners of the 11 million acres of private forestlands in Michigan to join the state’s Qualified Forest Program for timber harvesting and management was signed into law today. The nine-bill package, which includes a measure sponsored by Rep. Ed McBroom, R-Vulcan, updates the program’s property tax incentives and offers educational and technical assistance.The program is capped at 1.2 million acres but less than 80,000 acres have been enrolled in the program designed to ensure and increase a steady, sustainable supply of timber to an industry that generates $14 billion annually and directly employs 26,000 residents. The package includes Public Acts 42-50 of 2013. 06Jun Qualified Forest Program bills signed into law Categories: Newslast_img read more

Heath Robinson Memorial Bridge considered

first_img Categories: News 23Oct Heath Robinson Memorial Bridge considered House panel hears father, Foster testimony to honor war heroDan Robinson of joined state Rep. Frank Foster before the House Transportation Committee this week to provide testimony on naming the U.S.-2 bridge over the Cut River the Heath Michael Robinson Memorial Bridge. Heath was killed in action Aug. 6, 2011 in Afghanistan during a Navy SEAL rescue mission.The US-2 bridge crossing the Cut River in Mackinac County could be renamed to honor Heath Robinson, a 1995 Petoskey High School graduate and Navy SEAL who was killed in action Aug. 6, 2011 when a Chinook Helicopter he was in with about three dozen other military personnel was shot down in Afghanistan.State Rep. Frank Foster is working on House Bill 4957 with Hendricks Township residents and businesses to recognize Special Operator Senior Chief (Navy SEAL) Heath Michael Robinson’s service and sacrifice, while maintaining the legacy of the Cut River area.This week, Foster welcomed Robinson’s father, Dan Robinson, to provide testimony to the House Transportation and Infrastructure Committee on the legislation.“It would truly be an incredible honor for the Robinson family, the state of Michigan and the United States of America, to acknowledge a Michigan heroic warrior by aligning Heath with such a magnificent structure, the Cut River Bridge,” said Robinson of Emmet County. “People from coast to coast and around the world travel over this passage some 140 feet above the Cut River’s bottom and cruise the magnificent 600-feet plus span to safely arrive on the opposite side. I am  sure Heath would take great pride knowing he still is working diligently to protect and serve this great nation and her citizens, and this will be his new mission, always guarding against any foe, always protecting freedom!“Heath is buried in Arlington National Cemetery as a permanent memorial — the memorial bridge will pay tribute to all our fallen heroes, and the merger between Heath Michael Robinson and the Cut River Bridge will be a great story shared with visitors for years to come, with the pride for which this great nation was built.”The bridge is located about 25 miles west of the Mackinac Bridge and was selected for the memorial as a link to Heath’s great-grandfather and grandfather, who built bridges all over Michigan, according to his mother, Debora Robinson-Coxe of Moran Township, in written testimony. She said he also often traveled over this particular bridge often while visiting friends, and it served as a connection between Heath’s two favorite places – Mackinac Island and Coronado Island, California.“There are many similarities between my son, the warrior, and the bridge,” she wrote. “Heath was a Navy SEAL sniper; the bridge is located in a wooded area and is mostly hidden from view. Heath was silent, unpretentious, and did the job he loved, much like the Cut River Bridge. I can image his teammates repelling off it, climbing up it, or simply raising a glass at the base of the bridge to honor the memory of all the fallen heroes. Something to share is that even as brothers in arms, SEALS are extremely competitive, and the challenge of whose bridge is taller, wider, stronger, longer, or better looking brings a smile to my face, because at some 147 feet above the ground, Heath’s bridge might be one of the tallest. And I love that this bridge is close to home.”A 34-year-old chief petty officer, Robinson was born in Alma, MI, joined the U.S. Navy in January 1996 and served on six Special Warfare Units from 2000 to 2011.Robinson was killed while attempting to re-enforce U.S. Army Rangers under fire in the single largest loss of U.S. troops in the 10-year war in Afghanistan.He was buried at Arlington National Cemetery with full honors, leaving behind a wife, daughter, his parents and two brothers.Foster said the bill remains before the transportation committee while some technical revisions are worked out.“The loss of a father, husband, son, brother and friend can never be replaced,” said Foster, R-Petoskey. “Heath’s family, friends and all of us can be proud of his commitment to bring freedom and democracy to people throughout the world, and his sacrifice in serving to help rescue his comrades in arms. Memorializing Heath at the Cut River Bridge recognizes the life and memory of a special person at a special place.”last_img read more

Rep Miller joins law enforcement officers for Michigan House Sept 11 ceremony

first_imgPHOTO INFORMATION: State Rep. Aaron Miller of Sturgis was joined by local law enforcement officers for the Michigan House’s Sept. 11 Memorial Service. Pictured from left are St. Joseph County Capt. Jason Bingaman, St. Joseph County Undersheriff Mark Lillywhite, Rep. Miller, and Sturgis Director of Public Safety Geoff Smith. The observance held Sept. 6 at the state Capitol memorializes Michigan first responders and military members who died in the line of duty in the past year. Categories: Miller News,News 07Sep Rep. Miller joins law enforcement officers for Michigan House Sept. 11 ceremonylast_img read more

Good day And a Marvelous Monday to you Front and

first_imgGood day. And a Marvelous Monday to you! Front and Center. Happy Birthday to my darling daughter, Dawn. More at the end.  Cards lose in the 19th inning, they sure didn’t play very good baseball this weekend!  The weather was fabulosio this weekend in the St. Louis area, so we had that going for us. Chris heads to San Francisco later this week for the San Francisco Money Show.  I sure wish I were going too. I sure do love that city!Friday, we saw a lot of dollar buying to end the week. The currencies held the baton, orchestrating a gain for the week, until the dollar snuck up behind and snatched it away to end the week. The U. of Michigan Confidence report for the first two weeks of August, showed an increase and so did Leading Indicators for July. But I think it would be a stretch to think that those reports were the main reason the dollar rallied on Friday. Instead, I would think the reason could be placed squarely on the shoulders of book squaring.  But, the data didn’t hurt!This morning, the euro is a bit stronger, as most of the currencies are VS the U.S. dollar. The euro is getting a boost this morning from the rumors going around, that someone’s underground and, no wait! Darn-it Chuck, stick to the story! Well, the rumors this morning center around the ECB bond buying program, that just last week, Angela Merkel, said that Germany didn’t have any problems with, just might take place.The reports / rumors are talking about how the European Central Bank (ECB) is going to set limits for Eurozone debt yields, and pledge an unlimited amount of bond buying to maintain those limits. Whoa, there partner!  I sure hope they don’t make that announcement in public. Because I see all kinds of problems that could come of that! It’s far better to keep things like close to the vest and let the markets figure it out on their own.And Germany’s Central Bank, the Bundesbank, has opened up a line of criticism of the ECB, saying that “The Bundesbank holds to the opinion that government bond purchases by the Eurosystem are to be seen critically and entail significant stability risks.”Now. in the old days before the euro and the ECB were established. The Bundesbank was the cat’s meow. They controlled the monetary policy of the largest economy, and other central banks followed so closely to the Bundesbank that they could tell you what flavor gum the Bundesbankers were chewing! Holland, Denmark, Austria, and others had their central banks in the shadow of the Bundesbank. But. I’m afraid that’s all in the past. The ECB has the reins now. but, any kind of public debate will not be good for the euro.We have a couple of weeks before any decision is made there, as the ECB governing council will meet in September, and discuss this program. But, for now, the markets like what they’re hearing.  And the best performing currency overnight has been the Aussie dollar (A$). And after a week that saw the A$ lose ground, on statements by the Australian Treasurer about the currency being overvalued, the A$ fights to gain that lost ground back.  The Reserve Bank of Australia (RBA) meeting minutes will print tonight, so the markets will be going over those minutes to see if the RBA mentions the A$ strength.A Senior Currency Strategist at Westpac Banking Corp in Sydney had this to say about the A$… “While the Aussie might still be a little bit pricey at $1.04, I don’t think you want to be aggressive about short positions. I think the news out of Europe is getting a little better.”This is a big week in the Eurozone, as the German Chancellor (Merkel), and French President (Hollande) will meet this week, to discuss Greece. This meeting will come after both will have had separate meetings with Greek Prime Minister, (Samaras).   There is no revealing of Greece’s progress in cutting deficit spending / debt this week, that has to wait for the September publication of the Troika report on Greece’s progress. Remember, that if the Troika doesn’t believe that Greece has done enough they will hold back the next scheduled tranche of bailout funds for Greece.In addition, for those of you new to class. The Troika, is the name given to the members of the European Central Bank, The European Commission, and the IMF.  I know it might sound as though the rest of the Eurozone is ganging up on Greece, and being unfair to them. But. this framework was agreed to by the Greek leaders, in return for the second bailout funds.There’s not a lot of “meat” in the way of economic data reports this week in the U.S.  We will see some housing data, and Durable Goods later in the week. The biggest banana in the data bunch this week will be the meeting minutes of the last FOMC meeting.  Yes, all those notes will beU stale. but, will at least give the markets an idea of the frame of mind of the Fed Heads.OK.. moving along here. A dear reader, sent me a note the other day asking me, “if U.S. Treasury yields are rising, isn’t that good for the dollar?”  Well, yes, and no.  Yes, the dollar gets to fight with the other countries for yield differential trades. But, there’s a lot of trepidation here. how many false dawns have we seen in the past few years? Too many. too many times we’ve seen yields rise, only to be knocked back down again, and the markets are very well aware of that. So, they have not jumped in with both feet here. yet.  but if they do, they could give the dollar some love with the higher yields in Treasuries. But let me remind you what’s in the back of the minds of the market participants. The Fed participated in 61% of the Treasury auction last year. And they could turn the printing press on, and step up the buying at any time.  and for those of you that are going to throw a dart at me here. Yes,  I know there’s no actual printing press, it’s just a better way of describing the creation of dollars for the Fed to use to buy the Treasuries.I had another dear reader send me a note and to tell me how the Columbian economy is booming, and wanted me to list some Latin currencies in the currency roundup. Hmmm. if I keep adding currencies that list is going to get pretty large, and I’ll spend all morning, checking currency prices instead of writing!  But. We’ll add them to the Review & Focus currency dashboard. So, if you get the R&F, you’ll see them there starting in October. (we’ve already sent the September issue off to the printing press)  But I agree with the reader, Columbia has been on my list of countries that I’m watching, for over a year now. The currency is just so limited and fairly illiquid.  But that won’t stop me! I have a new MarketSafe CD coming out soon, get ready!The Japanese yen has been losing some ground in the past week.  As I told you in a Pfennig last week, the so-called “safe haven” destinations for money, that include yen, and Treasuries were getting sold.  Long time readers know that I threw in the towel on Japanese yen, as I kept saying that it was overvalued, and needed to weaken, and instead it would just get stronger VS the dollar. The Bank of Japan (BOJ) passed on their latest call for more stimulus at their last meeting, which didn’t help the yen.   I just think there are better currencies in Asia than yen. For the longest time, and I mean going back 20 years, when someone said they owned an Asian currency, you pretty much knew it was Japanese yen.  But it doesn’t have to be that way any longer!In that same vein. going back quite a few years. when someone said they owned a foreign currency, you pretty much knew they owned Swiss francs. (that is unless they recently took a trip to Canada or Mexico! HA!)  Swiss francs were the bees knees. But, then Switzerland was dwarfed by the Eurozone, and soon it became all about the euro. And. the Swiss National Bank (SNB) decided to hurt investors with a huge devaluation a year ago, and since then, we don’t get many people looking to buy francs.And then, I see where Bank of Canada (BOC) Gov. Carney will speak to Canadian Auto Workers Union this week.  You can bet that there will be calls to weaken the Canadian dollar / loonie. But, there’s not much the BOC can do. The loonie is stronger due to investors buying up Canadian bonds, as safe havens.  Now. in my opinion, which you know means I could be wrong, but in my opinion, Canada represents a safe haven much more than the Japanese yen, or U.S. Treasuries!  Yes, I truly understand that the size of the Japanese and U.S. bond markets dwarf Canada’s. But, given the strong banking sector in Canada, and the strong domestic demand of the economy, (we’ll see proof of that this week when Retail Sales prints) and steady government. safe haven is written all over Canada. again, that’s just my opinion!The price of Oil continues to climb higher, trading into the $96 handle this morning. There is talk now about the U.S. Gov’t releasing some of the oil reserves in an attempt to dampen the prices and prevent high energy costs, which could wipe out any gains the economy has made.Then There Was This. From The U.S. government’s debt held by foreign entities hit a record $5.2923 trillion in June, reported, citing Treasury Department data.In January 2009 the U.S. government owed $3.0717 trillion to foreigners entities, the news service added.China was the top creditor to the U.S. government, though Japanese entities were a close second.“Although the Chinese maintained their place as the top foreign owners of U.S. debt in June, they are not the top owners of U.S. debt in the world,” reported. “That distinction belongs to the U.S. Federal Reserve, which according to its July monthly report, owned $1.667 trillion in U.S. government debt in June.”Chuck again. I don’t know what scares me more. having so much of our debt held by foreigners, or by our own central bank!   I hear you saying, who do you want to own out debt, Chuck?  I don’t want debt to have to own!  Knowing that’s nearly impossible, I don’t know. I just don’t know. it’s like we’ve painted ourselves into a corner. if we step to the right, it’s bad, and if we step to the left it’s bad.  But then, I began warning about the growing debt in 2001.To recap. the currencies folded like a cheap tent on Friday to the dollar. Some second tier economic data was good for the dollar, but it had to be more than that driving the dollar higher. This morning, the currencies are attempting a move back at the dollar, as the ECB plan to buy bonds, is gaining traction, except with the Bundesbank.  The Aussie dollar is stronger this morning, and the RBA meeting minutes could give us a clue about the RBA’s feeling toward the strong A$.Currencies Today 8/20/12. American Style: A$ $1.0450, kiwi .8085, C$ $1.0115, euro 1.2310, sterling 1.5695, Swiss $1.0250, . European Style: rand 8.3120, krone 5.9370, SEK 6.6810, forint 225.65, zloty 3.3065, koruna 20.2370, RUB 32.08, yen 79.50, sing 1.2545, HKD 7.7570, INR 55.75, China 6.3590, pesos 13.10, BRL 2.0145, Dollar Index 82.63, Oil $96.13, 10-year 1.85%, Silver $28.14, and Gold $1,615.30That’s it for today. Yes, I won’t say how old my darling daughter Dawn is today, but she’s still looks like a young lady! Dawn shares a birthday, with our little Christine’s son, Jamieson. And Dawn’s college roommate, Kat, was in town yesterday, and it was her birthday, so we sang Happy Birthday to Dawn & Kat! So, birthdays all around!  The college football talk is really heating up, with all the anticipation of my beloved Missouri Tigers moving to the SEC this year. I sure hope they can be respectable in that league! It was great seeing Kat yesterday. When she attended Mizzou with Dawn, she came home with Dawn all the time, and it was like I had two daughters.  Oh, and Dawn’s husband, Jerry, wanted to be mentioned this morning too. HA!  I hope you all have a Marvelous Monday!Chuck Butler President EverBank World Markets 1-800-926-4922 read more

And one that seems particularly appropriate At

first_img And one that seems particularly appropriate: At 73, I can attest to the fact it is been a fun ride so far, and I am having too much fun to even think about getting off. Until next week… Our wealth is disappearing, and we need to speak up now. In a recent article for the Casey Daily Dispatch, I took Obama’s budget proposal and the effect it would have on Social Security to task. The president’s proposal offers three alternatives for funding Social Security – the Chained CPI; an expanded Social Security tax; or additional limits on IRA and 401(k) contributions. I don’t like any of these “solutions” one bit. In a recent Wall Street Journal article, Kelly Greene and Vipal Monga reported that pensions represent an increasingly smaller portion of Americans’ retirement savings. The authors wrote: “The portion of private-sector US workers covered only by so-called defined-benefit plans fell to 3% in 2011 from 28% in 1979, according to US Department of Labor data compiled by EBRI.” Unless you work for the government, pensions have gone the way of the dodo bird. Private-sector employers have switched from defined benefit plans to defined savings plans like 401(k)s and IRAs. If you don’t want to end up trying to survive on Social Security alone, you’re going to have to save quite a bit of money. And the financial shenanigans our government likes to pull make retiring even tougher. As I mentioned in my book, Retirement Reboot, when the government bailed out “too big to fail” banks, my retirement plan had to change radically. Treasuries and FDIC-insured CDs paying three times the inflation rate went out the window. Those safe, high-yield investments have gone the way of private-sector pension plans. To make matters worse, our annual Social Security cost of living increases don’t come close to covering rising expenses. The Chained CPI, moreover, would only further jerry-rig benefits, helping the spendthrift federal government at our expense. Many seniors have already taken a huge income cut as their portfolios struggle. Recently, my wife Jo and I looked at a 55-plus community on the outskirts of Phoenix. It was a pretty, upscale community – one we might be interested in. When Jo pulled up information on the community, some of data highlighted how much retirees are struggling. The statistics were: Population in 2010: 1,811 Population change since 2000: + 27.6% Median age of residents: 70.4 Estimated median household income in 2000: $86,248 Estimated median household income in 2009: $73,875 According to the Bureau of Labor Statistics’ (BLS) inflation calculator, if one had an income of $86,248 in 2000, one would have to earn $116,586 in 2013 to have the same buying power. Now, that is using the official – AKA bogus – government-calculated inflation rate. I shudder to think what the real figure is. Jo and I spoke with several realtors who said housing prices had escalated since 2000, but the population mix had not changed. It is safe to conclude that a household with the 2013 median income now has about 74% of the buying power it did in 2000. This only confirms what I see and hear from our subscribers all over the world. Many folks – baby boomers and seniors in particular – are understandably frightened.Enough Money to Enjoy Time with Your Grandchildren The first question in any retirement calculation is: “How much do we need to retire?” I think of the answer as a two-part number. First, how much do we need to survive? Second, how much do we need to enjoy a comfortable lifestyle where we don’t stress out about money, can visit our grandchildren, and can even do some fun stuff with them? Last summer we took two of our grandchildren to a Cubs game, and the tickets alone were $150 for the four of us. That does not include transportation, hot dogs, drinks, and souvenirs for the kids. While it was an unforgettable day, it was expensive. Even taking grandchildren to the movies and buying popcorn puts a dent in a lot of retirees’ budgets. It’s quite sad to hear stories about young grandchildren asking Grandma and Grandpa to take them on a trip or visit on their birthday, and the answer is “no” because of financial worries. Many folks who were positive they had enough money to retire comfortably have had to adjust their lifestyles. Too many retirees have simply had to hunker down into survival mode.Investing from the Inside Out I don’t want to spend too much time on the politics that affect retirement issues. However, we should all let our elected representatives know how we feel. Most of us worked hard, played by the rules, and saved our money. Our Social Security benefits should not be reduced or taken away because our government can’t rein in its reckless spending. While we do not have direct control over Congress, we can control how we manage our life savings. There is no way to sugarcoat the fact that it takes work. We all have to manage and invest our life savings wisely, or risk losing it along with our retirement dreams. While many folks have already cut expenses and are looking for alternative sources of income, some are still overlooking the best investment they can make: investing in themselves. That means not blindly throwing money into a “black box” mutual fund; we have to actually learn about our investments now. Don’t let the process intimidate you. The education and skills that allowed us to build our nest eggs will also help us make it last. Learning about our investments is no different from learning about the thousands of other things we already know; we just need to put in the time, energy, and resources. Stockbrokers have been feeding us a line for too many years. They don’t have secret information or some sort of magic formula. The only magic formula is education and hard work.The Money Forever Plan Our subscribers have voiced their needs loud and clear. Every day more folks are taking the time to invest in themselves. They are no longer blindly investing their nest eggs. They want more than just another newsletter that gives stock tips; they want to know how to manage a retirement portfolio over the long haul. Our subscribers want the most out of retirement, and we work alongside them to make sure they get it. The folks who are thriving during retirement are the ones who have stepped up and embraced the learning curve. “Set it and forget it” is now a surefire way for our retirement dreams go up in smoke. In the April issue of Miller’sMoney Forever, we looked at portfolio allocation and the nuances of diversified investing. We took an in-depth look at why we had recommended certain investments, where they fit in our portfolio, and what percentage of our portfolio each pick should represent. The Money Forever portfolio is diversified, safe, and full of income-producing investments, but that’s just the starting point. We also walk you through how to incorporate our recommendations and tactics into your existing portfolio. Just a few minutes each day spent learning how to invest your money wisely can provide a huge return on our time and money. Many subscribers have been kind enough to send us testimonials outlining how well they have done with some of our picks. Every hour they invest in educating themselves pays dividends (pun intended). The solution is so simple that it baffles me why more folks don’t catch on. Once you educate yourself, you have the skills and confidence to make your own investment decisions. You never again have to wonder if the real reason your stockbroker called you about a hot stock was to generate a commission. Instead, each investment decision you make will be based on sound logic. I’d like to thank our readers for their feedback and suggestions. You’ve made it clear that, in addition to some doggone good stock recommendations, you also want an education on how to retire successfully. So please, keep the emails coming. The more you share concepts or products you want us to explain or focus on, the better job we can do for you. I am one of you, a retiree who came to Casey Research looking for answers. When we recommend a stock, we invest right along with you, but only after our requisite, companywide waiting period has elapsed. Seniors and savers, we are all in this together. I spent most of my career teaching adults, and I know that complicated information can be taught in simple, easy-to-follow ways. I don’t know about you, but geek talk just frustrates me. That’s why we explain money matters in plain English, so there’s no need to get a Ph.D. in economics or keep an investment dictionary handy when you subscribe. I’m sure we have all told our children and grandchildren that an education is one thing that can never be taken away. In our case, a financial education can keep us independent and in the game (and, if we want, we can take the grandchildren along). The current the price of a subscription is affordable – less than that of a typical morning newspaper. The best part is you can take advantage of our 90-day, no-risk offer. You can cancel for any reason, no questions asked, within the first 90 days. As you might expect, our cancellation rates are very low, and we aim to keep it that way.On the Lighter Side For those who are fans of the Hostess Twinkie, they should be back in grocery stores sometime late this summer. I have never been a Twinkie lover, but I have never been unable to eat just one Ho-Ho in a package of two. My wife Jo tells me they come two to a package so they can be shared. Yeah, right! I buy two packages, and we can share that way. We are now back in Illinois for the summer, where I grew up. A friend recently said something to the effect that I was “going home for the summer.” I had to stop for a moment as I realized I no longer look at it as home. It has gone through so many changes in my 73 years that it is more like a place where I have fond memories. It’s just not the simple, easy life like it was when I was growing up. And finally… I have mentioned our friend Toots many times, who was a high school classmate of mine. She was younger, and graduated at 17 among the top five in our class. I like to remind her that it was folks like me who helped make the upper half of the class possible. We made the mistake of making fun of her because of her young age, as she had to wait a year longer to get her driver’s license. She is now getting her revenge. Knowing I had a birthday recently, she sent me some bumper stickers reminding me that I was one of the older folks in our class.last_img read more

Pureport Announces Feature Enhancements to Its OnDemand Cloud Connectivity Platform

first_imgNewFunctionality Includes Cloud Grade NAT for IP Address Conflict ResolutionMulticloud Networking Provider Pureport announced major feature enhancements to its Multicloud Fabric platform which enables seamless orchestration of private connectivity to the major cloud providers. Pureport’s Multicloud Fabric empowers businesses of all sizes to securely interconnect clouds, sites, and on-premises facilities in minutes, without the need for additional physical infrastructure.Multicloud, hybrid cloud, and multi-site networks are often configured with overlapping IP address ranges. To solve this common obstacle, Pureport’s new product enhancements include Cloud Grade NAT functionality, a feature that intelligently detects and resolves overlapping IP address conflicts. By mitigating these conflicts, organizations can avoid significant expense, and immediately proceed with network interconnection.“Enabling the new Cloud Grade NAT functionality for a connected network is as simple as checking a box in our console, which is just one example of how these features are truly evolving the way cloud networks are built,” said Doug Mittendorf, CTO of Pureport. “A great application of the Cloud Grade NAT functionality is to support SaaS providers who offer private connectivity to their customers, where the SaaS provider has no control over the customer networks. With Cloud Grade NAT, this is no longer an issue.”Marketing Technology News: Airtame Adds Power over Ethernet Product to Their ServicesIn this latest release, Pureport’s Console has been enhanced to make it even easier to build and deploy multicloud, hybrid cloud, and multi-site networks within minutes. The Console now offers a user-friendly, visual tool to manage cloud networks, thereby reducing the administrative overhead and technical expertise often required when deploying traditional networks.“Cloud networking is becoming more and more challenging as organizations attempt to marry multiple dispersed technologies, and we’re on a mission to remove the common obstacles organizations face today when creating and managing cloud networks—specifically time to deployment, and excessive expenses incurred in deployment and management,” said Rich Lee, CEO of Pureport. “This latest version of Pureport’s platform addresses industry feedback and makes cloud networking easier, faster, and more affordable.”Marketing Technology News: Jumio, Monzo Partnership Grows to New HeightsAdditional Key Feature Enhancements of Pureport’s Multicloud Fabric include:Layer 3 Networking – All Pureport gateways now support BGP Peering to allow for dynamic exchange of routes with edge routers, as well as between other gateways across an organization’s private network. Cloud connections support automatic failover between redundant gateways and allow all edge routers to dynamically learn the routes to all interconnected subnets.Automated BGP Configuration – Pureport’s Distributed Multicloud Router simplifies network configuration and deployment by assigning network subnets, discovering autonomous system numbers, and automatically configuring BGP sessions on the administrator’s behalf.High Availability – Every connection within a Pureport network is highly available by default, where each connection has two gateway containers across separate availability zones. Traffic will continue to flow, even if a failure—such as a power outage, provider circuit loss, switch failure, engine failure, etc.—occurs in one of the two zones.Power Seamless Integrations with Existing Orchestration and Automation Systems –Pureport now exposes a simple REST API, allowing for DevOps automation of multicloud and hybrid cloud networks using existing orchestration and automation tools.Expanded RegionsPureport’s Multicloud Fabric is deployed to five key interconnection facilities (San Jose, Seattle, Washington DC, Chicago, and Dallas) with a full-mesh backbone between all locations. This allows for low-latency, private connectivity between all public cloud regions in the US.Marketing Technology News: Cheetah Digital Strengthens EMEA Team With Three Executive Additions Pureport Announces Feature Enhancements to Its On-Demand Cloud Connectivity Platform PRNewswireMay 8, 2019, 8:04 pmMay 8, 2019 Marketing TechnologyMulticloud Fabric platformMulticloud NetworkingNewsphysical infrastructurePureportRich Lee Previous ArticleAudio Visual Solutions Company, IVCi, Explains How Companies Can Leverage Video Walls to Increase Room FunctionalityNext ArticleLinda Avery, Chief Data Officer at the Federal Reserve Bank of New York, Named US Chief Data Officer of the Year 2019 by CDO Clublast_img read more

Immunotherapy increases survival in some patients with metastatic triple negative breast cancer

first_img Source: Reviewed by James Ives, M.Psych. (Editor)Oct 22 2018Immunotherapy improves survival in some patients with metastatic triple negative breast cancer, according to late-breaking results from the IMpassion130 trial reported at the ESMO 2018 Congress in Munich.Prof. Peter Schmid, first author, said the results “will change the way triple-negative breast cancer is treated”. “Atezolizumab in combination with nab-paclitaxel is the first targeted treatment to improve survival in metastatic triple negative breast cancer,” said Schmid, Clinical Director of London’s St. Bartholomew’s Breast Cancer Centre, Barts Health NHS Trust, UK and lead of the Centre for Experimental Cancer Medicine, Barts Cancer Institute, Queen Mary University of London, UK. “It is also the first immune therapy to improve outcome in this cancer. Most of the survival benefit was in patients with PD-L1 positive tumors.”Triple negative breast cancer is the most aggressive type of breast cancer. It is relatively rare and often affects younger women. Once the disease becomes metastatic, the median survival is around 12 to 15 months. Triple negative breast cancer does not have receptors for the hormones oestrogen or the protein HER2, meaning it cannot be treated with hormone therapy or drugs targeting HER2. The main drug treatment is chemotherapy and most patients develop resistance to chemotherapy within a few months.The phase III IMpassion 130 trial enrolled 902 patients with metastatic triple negative breast cancer who had not received prior treatment for metastatic disease. Patients were randomly allocated to standard chemotherapy (nab-paclitaxel) plus atezolizumab, an antibody targeting the protein PD-L1, or to standard chemotherapy plus placebo. The two main objectives were to see whether the drug combination could slow cancer growth (progression-free survival) and prolong life (overall survival) in all patients and in those expressing PD-L1. The median follow-up was 12.9 months.The combination therapy reduced the risk of disease worsening or death by 20% in all patients and 38% in the subgroup expressing PD-L1. In the entire study population, the median progression free survival was 7.2 months with the combination and 5.5 months with chemotherapy alone, with a hazard ratio (HR) of 0.80 (p=0.0025). In the PD-L1 positive group, the median progression free survival was 7.5 months with the combination and 5.0 months with chemotherapy alone (HR 0.62, p<0.0001).More than half of patients were alive at the time of analysis, so this was an interim assessment of overall survival. In patients with PD-L1 positive tumors, the median overall survival was 25.0 months with the combination compared to 15.5 months with standard chemotherapy alone (HR 0.62). In all patients, survival was 21.3 months with the combination versus 17.6 months with chemotherapy alone which was not statistically different, likely because of the short follow-up.Related StoriesStudy reveals link between inflammatory diet and colorectal cancer riskSpecial blood test may predict relapse risk for breast cancer patientsSugary drinks linked to cancer finds studyThe proportion of patients responding to treatment (objective response rate) was higher with the combination compared to chemotherapy alone for all patients (56% versus 46%) and those with PD-L1 positive tumors (59% versus 43%).Schmid said the combination therapy was well tolerated. Most side effects were due to chemotherapy and occurred at a similar rate in both treatment groups, although there was a minor increase in nausea and cough in the combination group. Side effects related to immune therapy were rare, the most common being hypothyroidism which occurred in 17.3% of patients receiving the drug combination and 4.3% receiving chemotherapy alone.Schmid said: "Immune therapy on top of standard chemotherapy prolonged survival by ten months in patients with tumors expressing PD-L1. This combination should become a new treatment option for patients with metastatic triple negative breast cancer."Commenting on the results for ESMO, Dr Marleen Kok, Medical Oncologist, The Netherlands Cancer Institute, Amsterdam, said: "This is the first randomized phase III trial providing evidence that adding immune therapy to standard chemotherapy increases progression-free survival in metastatic triple negative breast cancer, particularly in patients with PD-L1 positive tumours, and extends overall survival in the PD-L1 positive subgroup. While the benefit in terms of progression-free survival was relatively small, around three months, the gain in overall survival in the PD-L1 positive subgroup was impressive with a ten-month benefit. Around 40% of the tumours were PD-L1 positive. The IMpassion 130 data will probably change the treatment landscape for our metastatic triple negative breast cancer patients."Kok noted that it is still not clear what the best chemotherapy backbone is for anti-PD-(L)1 treatment and that many trials are ongoing, evaluating the additional effect of anti-PD-(L)1 on top of chemotherapy in metastatic breast cancer but also for early breast cancer patients. "This should help answer the question of which chemotherapy backbone is most effective in combination with anti-PD-(L)1." she said. "We also need more studies to determine a biomarker for selecting patients most likely to benefit from this treatment."last_img read more

Novel personalized medicine tool for assessing inherited colorectal cancer syndrome risk developed

first_img Source: Reviewed by Alina Shrourou, B.Sc. (Editor)Dec 10 2018An international team of researchers led by Huntsman Cancer Institute (HCI) at the University of Utah (U of U) has developed, calibrated, and validated a novel tool for identifying the genetic changes in Lynch syndrome genes that are likely to be responsible for causing symptoms of the disease. The results were published this week in the journal Genetics in Medicine.Lynch syndrome is a hereditary condition that results in higher rates of colon, endometrial, and other cancers. If unmanaged, individuals with Lynch syndrome have a 75 percent lifetime risk of developing colorectal cancer. It is believed that approximately five percent of all colorectal cancer cases are associated with this syndrome.Millions of distinct changes are possible in genes that control health, and it is a massive undertaking to identify which specific changes are associated with developing disease. Some genetic changes are believed to have no impact at all, while others carry significant risk.Researchers at Huntsman Cancer Institute work to understand and classify which gene changes are likeliest to cause disease, as well as to identify appropriate strategies to help manage disease risk.This groundbreaking study was led by Sean Tavtigian, PhD, a cancer researcher at HCI and professor of oncological sciences at the U of U. The work was built on a decade-long international collaboration. “Correctly identifying which of the genetic changes we observe actually result in disease is fundamentally important in clinical care,” said Tavtigian. “Having clarity on this issue has the potential to add years to patients’ lives, reduce anxiety about disease risk, and use health care dollars more efficiently.”Related StoriesAdding immunotherapy after initial treatment improves survival in metastatic NSCLC patientsSugary drinks linked to cancer finds studyCancer killing capability of lesser-known immune cells identifiedThe team used a laboratory test previously developed by the group of Niels de Wind, PhD, associate professor of human genetics at the Leiden University Medical Center in The Netherlands, to characterize genetic changes associated with disease risk. The lab test, called the Cell-free in vitro MMR Activity (CIMRA) assay, improves classification of variants of uncertain significance in Lynch syndrome. “The test is rapid and accurate,” said de Wind. In the current study, the test was thoroughly calibrated and validated, such that its results could now be integrated with computer-based modeling and clinical data. As a result, this study provides an analytical tool suitable for clinical use to assess the potential of changes in Lynch syndrome genes to cause disease.”A key point is that we believe the accuracy of the tool combining the CIMRA test with the previously published computational analysis to be about 97 percent, making it appropriate for clinical use,” said Tavtigian. de Wind added that the work “represents a new pinnacle in the classification of genetic variation.”The authors believe that routine utilization of their methods will dramatically increase the rate of risk classification for genetic changes that previously were poorly understood. Moreover, this calibration strategy provides a template for the development, validation, and calibration of reliable strategies for the diagnostic assessment of other hereditary cancer predisposition syndromes and genetic disorders.last_img read more

Measures of biochemical hypoglycemia linked to high risk of severe hypoglycemic events

first_imgReviewed by James Ives, M.Psych. (Editor)Jan 10 2019Researchers have shown that measures of biochemical hypoglycemia in fingerstick blood samples are associated with an increased risk of severe hypoglycemic events. The results of this new study, which further emphasize the dangers of hypoglycemic blood glucose levels, are published in Diabetes Technology & Therapeutics (DTT), a peer-reviewed journal from Mary Ann Liebert, Inc., publishers. Click here to read the full-text article free on the Diabetes Technology & Therapeutics (DTT) website through February 9, 2019.Related StoriesUranium toxicity might have caused obesity and diabetes in Kuwait, finds new studyAADE’s comprehensive guidance on care of children, young adults with diabetes releasedDiabetes patients experiencing empathy from PCPs have beneficial long-term clinical outcomesRoy Beck, MD, PhD, Jaeb Center for Health Research (Tampa, FL), Richard Bergenstal, MD, International Diabetes Center Park Nicollet (Minneapolis, MN), and Tonya Riddlesworth, PhD and Craig Kollman, PhD, Jaeb Center for Health Research, present their findings in the article entitled “The Association of Biochemical Hypoglycemia with the Subsequent Risk of a Severe Hypoglycemic Event: Analysis of the DCCT Data Set.” The researchers used two different levels of biochemical hypoglycemia – <70 or <54 mg/dL - to determine the relationship to severe hypoglycemic events. When either level was present, the risk of severe hypoglycemic events was significantly higher."Severe hypoglycemia is a significant hurdle for intensifying insulin therapy in patients with T1D. Beck and colleagues emphasize the increased risk of future severe hypoglycemia in patients with any level of biochemical hypoglycemia," says DTT Editor-in-Chief Satish Garg, MD, Professor of Medicine and Pediatrics at the University of Colorado Denver (Aurora).Source: read more