Ateneo rips NU

first_imgMOST READ Lyceum targets finals berth BSP sees higher prices in November, but expects stronger peso, low rice costs to put up fight Read Next Brace for potentially devastating typhoon approaching PH – NDRRMC Fire hits houses in Mandaluyong City Trending Articles PLAY LIST 00:50Trending Articles00:50Trending Articles00:50Trending Articles01:37Protesters burn down Iran consulate in Najaf01:47Panelo casts doubts on Robredo’s drug war ‘discoveries’01:29Police teams find crossbows, bows in HK university01:35Panelo suggests discounted SEA Games tickets for students02:49Robredo: True leaders perform well despite having ‘uninspiring’ boss02:42PH underwater hockey team aims to make waves in SEA Games Earlier, Adamson got back on the winning track after surviving a gritty challenge from University of the East, 66-57, to solidify its hold of third spot with a 6-3 record.The victory augurs well for the Falcons as they brace for a crucial clash with La Salle on Saturday, even as the Warriors saw their two-game winning run halted for a 2-7 record.“As you can see, it was a dogfight,” said Adamson coach Franz Pumaren. “It was really a struggle. It’s a good thing that we made some important stops in the end.”ADVERTISEMENT Ateneo didn’t look like it was in a rush to put away National U last Wednesday.ADVERTISEMENT Don’t miss out on the latest news and information. center_img But the pacesetting Blue Eagles’ latest victory in UAAP Season 80 took on a familiar theme: A close game for three quarters, before they methodically picked apart another opponent down the stretch.Thirdy Ravena fired 12 of his 15 points in the second half and the Eagles held the Bulldogs to just seven points in the final period on the way to an 85-72 victory that assured Ateneo of at least a playoff for a Final Four berth at Mall of Asia Arena.FEATURED STORIESSPORTSWATCH: Drones light up sky in final leg of SEA Games torch runSPORTSSEA Games: Philippines picks up 1st win in men’s water poloSPORTSMalditas save PH from shutoutMatt Nieto and Jolo Mendoza combined for 20 points, including five treys for the Eagles, who trailed at the end of the first half, 45-48, for the first time this season before making the Bulldogs bleed for their points in the last two quarters.The win lifted the Eagles to 9-0, while sending the Bulldogs to their sixth loss in nine games, putting their Final Four hopes in peril. Typhoon Kammuri accelerates, gains strength en route to PH Frontrow holds fun run to raise funds for young cancer patients  Nonong Araneta re-elected as PFF president Kin of Misamis Oriental hero cop to get death benefits, award — PNP Kammuri turning to super typhoon less likely but possible — Pagasa LATEST STORIES View commentslast_img read more

US swimmer Katie Ledecky breaks 400-metres freestyle world record

first_imgThe 17-year-old swimmer also holds the world records in the 800 and 1,500 freestyle eventsKatie Ledecky lowered her own world record in the women’s 400-metres freestyle to win the Pan Pacific championships title in 3 minutes, 58.37 seconds on Saturday.Ledecky was under world-record pace for much of the race in an outdoor pool at the Gold Coast Aquatic Centre and finished strongly to shave almost a half-second off the mark of 3:58.86 she set at the US nationals on Aug. 14.The 17-year-old Ledecky also holds the world records in the 800 and 1,500 freestyle events, and narrowly missed improving her mark in the 800 earlier at the Pan Pacs.”It’s a great feeling. It never really gets old,” Ledecky said of her run of records. “I have some long-term goals. We’re not quite there yet, but we’ll get there.”Cierra Runge congratulates her teammate Katie Ledecky for her new world recordIt was her fourth gold medal of the meet, following her titles in the 200, 800 and the 4×200-meter relay.Persistent rain has overshadowed the meet since the opening day but it wasn’t raining Saturday night during the 400 – not that it would have bothered Ledecky.”It was beautiful out there tonight. I’m not really affected by the rain or anything,” she said. “there’s no rain under water, so it doesn’t really bother me.”Ledecky won the 800 meters at the London Olympics and added gold medals in the 400, 800 and 1,500 at last year’s world championships, where she also lowered the world records over the two longer distance events.advertisementHer swim on Saturday gave her another first – for a world record in the new pool that will be used for the 2018 Commonwealth Games.”Oh yeah, I didn’t even think about that. I guess that is pretty neat,” she said. “It’s a nice pool. I’m loving it here in Australia – it’s been a fun week.”last_img read more

a month ago​Henderson denies Liverpool favourites for UCL

first_img​Henderson denies Liverpool favourites for UCLby Ansser Sadiqa month agoSend to a friendShare the loveLiverpool captain Jordan Henderson does not see his side as being the favourites to win the Champions League.The Reds are defending their European crown, which only Real Madrid has managed in recent memory.While they are still blessed with an incredibly talented squad, Henderson does not see them as being the de facto favourites.Henderson said the following to the club’s official website: “I think it’s too early to be saying stuff like that. “For us, we’ve started the season really well and we just want to continue that on. “We still feel we can improve and still get better, so that’s what we try to do tomorrow night, try to give everything and start the campaign off really well. On Tuesday’s first Champions League clash of the season against Napoli, the Englishman added: “Maybe [we are favourites], but I feel as though being at Liverpool, everybody wants to beat you anyway. It’s the same for us – we want to beat everybody we play, they want to beat us.”For us, it’s the same as it always has been – to give everything in every single game we play. “We know that it’ll be a tough game tomorrow, they’re a great side but we’ve got to concentrate on what we can do. If we can perform to the level I know we can then we have a good opportunity to win the game.” About the authorAnsser SadiqShare the loveHave your saylast_img read more

a month agoAntoine Griezmann happy with Barcelona win: We’re getting better

first_imgAbout the authorCarlos VolcanoShare the loveHave your say Antoine Griezmann happy with Barcelona win: We’re getting betterby Carlos Volcanoa month agoSend to a friendShare the loveAntoine Griezmann was happy to score in Barcelona’s 2-1 win over Villarreal.Griezmann struck just six minutes into the game. Later, Barcelona scored again thanks to a goal from Arthur. Villarreal later pulled back a goal thanks to Santi Cazorla.”We had some chances to extend our lead but we didn’t take them,” Griezmann said to Movistar+. “But we’re going to keep on getting better. We can do much better than this. We have to keep on working hard. There are new players, we’ve just got here and we have to keep on working hard.”In reference to what Barça are lacking at the moment, he added: “A lot of us have just got to the club. It’s about adjusting to the style as quickly as possible. We’re a long way from our best but with time we will keep getting better.” He recognised that it’s different from what he was used to at Atletico Madrid: “The football is different. I knew it would be hard and that I would only get better with games. It’s not going too badly, though. Three goals. Now to keep getting better. That’s the path.” last_img read more

Cabinet to Consider Amendment to Contractor General Act

first_imgCabinet is to consider a submission to amend the Contractor General Act, aimed at protecting the business secrets of investors during the pre-contract stage.This was disclosed by Attorney General, Patrick Atkinson on Wednesday, May 29, during his contribution to the 2013/2014 Sectoral Debate in the House of Representatives.He explained that the intention is to limit the involvement of the Office of the Contractor General (OCG) in certain investment opportunities at the pre-contract stage.He assured that the move will not prevent the OCG from taking action on any breaches.Mr. Atkinson noted that there are “several strategic investments at hand” and several others to come, and “when such investment opportunities are in the formative and feasibility stages, confidentiality is usually demanded by those seeking to do business with the Government”.“More often than not, they require protection of their business and production secrets, from their competitors,” he pointed out.Mr. Atkinson added that they may also wish to be assured that they will be fast-tracked towards approval or rejection and ask for the prevention of unnecessary bureaucratic delays.He noted that the question of Cabinet’s confidentiality and the possibility of premature publication by press release of sensitive proprietary information before completion of the process, would also be clarified.“Towards this end, I have received permission to say that the Minister of Transport, Works and Housing, Dr. the Hon Omar Davies, will present a submission to Cabinet to amend the Contractor General Act, which will not preclude the OCG from a complete review of the process when it is concluded, and will not compromise the OCG’s ability to take appropriate action if a breach is detected,” the Attorney General said.“This proposed amendment to the Act will satisfactorily dispose of the issues of concern in the existing legal action, which is now before the court. If Cabinet finds favour with the Minister’s submission and the matter is referred to Chief Parliamentary Counsel for drafting, I would, in a timely manner, seek the Cabinet’s permission to file an application to discontinue the current court action against the OCG”.The Minister of Transport, Works and Housing, has applied to the Full Court of the Supreme Court for a re-hearing in a matter against the OCG for interpretation of certain sections of the Contractor General Act.Contact: Latonya Lintonlast_img read more

Damen Takes the Helm at Curaçao Yard

first_imgzoom Damen Shiprepair & Conversion (DSC) has taken over the management of the Curaçao Droogdok Maatschappij (CDM) as of February 1st, 2017, some five months after Damen Shipyards Group and the government of Curaçao agreed on the transaction.The company said that the yard, located on the route to the Panama Canal, will continue its activities under the name of Damen Shiprepair Curaçao (DSCu).The yard features two graven docks and almost 2 kilometres of quay side. In the coming years Damen is set to invest around USD 40 million in a third floating dock and the yard’s infrastructure and equipment.“The cooperation between Damen, the Curaçao government, local trade unions and the personnel of the yard has been very pleasant during the period of negotiations and transfer of ownership. We are very much looking forward to continuing this collaboration in the future. It is excellent to see the enthusiasm of all parties to make this yard such a success,” Durk-Jan Nederlof, Group Director Damen Shiprepair & Conversion, said.Furthermore, the company said that it will, together with the Curaçao government, invest in training and schooling of local technical personnel.Damen Shiprepair Curaçao is part of the Damen Shiprepair & Conversion group, which currently operates 42 dry docks in 16 shipyards worldwide.last_img read more

Weekly Summary Corporate dividends name changes new listings

first_imgNEW YORK — Changes announced in corporate dividends Nov. 26-Nov. 30.INCREASED DIVIDENDSCB Financial Services .23 from .22C&F Financial .37 from .36Capital Southwest .36 from .34La-Z-Boy Inc .13 from .12Four Corners Property Tr .2875 from .275OFG Bancorp .07 from .06McCormick & Co .57 from .52Meridian Bancorp .07 from .05Nucor Corp .40 from .38Quest Diagnostics Inc .53 from .50RGC Resources .165 from .155Saratoga Investment .53 from .52Walt Disney Co .88 from .84York Water .1733 from .1666SPECIAL DIVIDENDSAssd Banc Dep pfd DDiamond Hill Investment 8.00First BanCorp Puerto Rico .03First Northwest Bancorp .03Fulton Financial .04GrafTech International .70Haverty Furniture Cl A .95Haverty Furniture 1.00Investors Title 10.60National Beverage 2.90Saga Communications Cl A .25TPG Specialty Lending .05United Bancorp .05STOCK DIVIDENDSCass Info Systems 20pcLandmark Bancorp 5pcg- Canadian fundsOTHER CORPORATE NEWS AND LISTINGS:STOCK SPLITS THIS WEEKItau Unibanco Holdings SA 3 for 2 splitTonix Pharmaceuticals Hldgs 1 for 10 reverse splitACQUISITIONS AND MERGERSMINIMUM VALUE $300 MILLIONAetna Inc – CVS Health Corp (70B)AmTrust Financial Services Inc – Evergreen Parent LP (3B)Rockwell Collins Inc – United Technologies (30B)NEW STOCK LISTINGSNYSEBraemar Hotels & Resorts Inc pfd DNASDAQ GLOBAL AND GLOBAL SELECT MARKETSEnstar Group Ltd ADS 7pc pfd ESTOCKS REMOVED FROM TRADINGNYSEJones Energy IncNASDAQ GLOBAL AND GLOBAL SELECT MARKETSAnchor BancorpCorium International IncTeradyne Inc (from NYSE)CORPORATE NAME CHANGESI-AM Capital Acquisition Co to Smaaash Entertainment (and warrants)The Associated Presslast_img read more

March 31 2017DOCOMOMO US National Symposium visit

first_imgMarch 31, 2017DOCOMOMO US National Symposium visits Arcosanti.The Docomomo US National Symposium is the primary event in the United States for professionals to discuss and share efforts to preserve modern architecture and meet leading practitioners and industry professionals.[photos by Leah-Ann Walker]The Fifth Annual Docomomo US National Symposium entitled “Modernism and Climate” is taking place in Phoenix, AZ from March 29. through April 2. 2017.It will look at how modern design approached desert climates creatively and how thos design strategies continue to be relevant in light of our search for sustainable solutions and what can be learned from those creative efforts.The only national event dedicated to all aspects of the preservation of Modernism, the symposium brings together world renowned designers, scholars, students and professionals from around the country.last_img read more

Good day And a Marvelous Monday to you Front and

first_imgGood day. And a Marvelous Monday to you! Front and Center. Happy Birthday to my darling daughter, Dawn. More at the end.  Cards lose in the 19th inning, they sure didn’t play very good baseball this weekend!  The weather was fabulosio this weekend in the St. Louis area, so we had that going for us. Chris heads to San Francisco later this week for the San Francisco Money Show.  I sure wish I were going too. I sure do love that city!Friday, we saw a lot of dollar buying to end the week. The currencies held the baton, orchestrating a gain for the week, until the dollar snuck up behind and snatched it away to end the week. The U. of Michigan Confidence report for the first two weeks of August, showed an increase and so did Leading Indicators for July. But I think it would be a stretch to think that those reports were the main reason the dollar rallied on Friday. Instead, I would think the reason could be placed squarely on the shoulders of book squaring.  But, the data didn’t hurt!This morning, the euro is a bit stronger, as most of the currencies are VS the U.S. dollar. The euro is getting a boost this morning from the rumors going around, that someone’s underground and, no wait! Darn-it Chuck, stick to the story! Well, the rumors this morning center around the ECB bond buying program, that just last week, Angela Merkel, said that Germany didn’t have any problems with, just might take place.The reports / rumors are talking about how the European Central Bank (ECB) is going to set limits for Eurozone debt yields, and pledge an unlimited amount of bond buying to maintain those limits. Whoa, there partner!  I sure hope they don’t make that announcement in public. Because I see all kinds of problems that could come of that! It’s far better to keep things like close to the vest and let the markets figure it out on their own.And Germany’s Central Bank, the Bundesbank, has opened up a line of criticism of the ECB, saying that “The Bundesbank holds to the opinion that government bond purchases by the Eurosystem are to be seen critically and entail significant stability risks.”Now. in the old days before the euro and the ECB were established. The Bundesbank was the cat’s meow. They controlled the monetary policy of the largest economy, and other central banks followed so closely to the Bundesbank that they could tell you what flavor gum the Bundesbankers were chewing! Holland, Denmark, Austria, and others had their central banks in the shadow of the Bundesbank. But. I’m afraid that’s all in the past. The ECB has the reins now. but, any kind of public debate will not be good for the euro.We have a couple of weeks before any decision is made there, as the ECB governing council will meet in September, and discuss this program. But, for now, the markets like what they’re hearing.  And the best performing currency overnight has been the Aussie dollar (A$). And after a week that saw the A$ lose ground, on statements by the Australian Treasurer about the currency being overvalued, the A$ fights to gain that lost ground back.  The Reserve Bank of Australia (RBA) meeting minutes will print tonight, so the markets will be going over those minutes to see if the RBA mentions the A$ strength.A Senior Currency Strategist at Westpac Banking Corp in Sydney had this to say about the A$… “While the Aussie might still be a little bit pricey at $1.04, I don’t think you want to be aggressive about short positions. I think the news out of Europe is getting a little better.”This is a big week in the Eurozone, as the German Chancellor (Merkel), and French President (Hollande) will meet this week, to discuss Greece. This meeting will come after both will have had separate meetings with Greek Prime Minister, (Samaras).   There is no revealing of Greece’s progress in cutting deficit spending / debt this week, that has to wait for the September publication of the Troika report on Greece’s progress. Remember, that if the Troika doesn’t believe that Greece has done enough they will hold back the next scheduled tranche of bailout funds for Greece.In addition, for those of you new to class. The Troika, is the name given to the members of the European Central Bank, The European Commission, and the IMF.  I know it might sound as though the rest of the Eurozone is ganging up on Greece, and being unfair to them. But. this framework was agreed to by the Greek leaders, in return for the second bailout funds.There’s not a lot of “meat” in the way of economic data reports this week in the U.S.  We will see some housing data, and Durable Goods later in the week. The biggest banana in the data bunch this week will be the meeting minutes of the last FOMC meeting.  Yes, all those notes will beU stale. but, will at least give the markets an idea of the frame of mind of the Fed Heads.OK.. moving along here. A dear reader, sent me a note the other day asking me, “if U.S. Treasury yields are rising, isn’t that good for the dollar?”  Well, yes, and no.  Yes, the dollar gets to fight with the other countries for yield differential trades. But, there’s a lot of trepidation here. how many false dawns have we seen in the past few years? Too many. too many times we’ve seen yields rise, only to be knocked back down again, and the markets are very well aware of that. So, they have not jumped in with both feet here. yet.  but if they do, they could give the dollar some love with the higher yields in Treasuries. But let me remind you what’s in the back of the minds of the market participants. The Fed participated in 61% of the Treasury auction last year. And they could turn the printing press on, and step up the buying at any time.  and for those of you that are going to throw a dart at me here. Yes,  I know there’s no actual printing press, it’s just a better way of describing the creation of dollars for the Fed to use to buy the Treasuries.I had another dear reader send me a note and to tell me how the Columbian economy is booming, and wanted me to list some Latin currencies in the currency roundup. Hmmm. if I keep adding currencies that list is going to get pretty large, and I’ll spend all morning, checking currency prices instead of writing!  But. We’ll add them to the Review & Focus currency dashboard. So, if you get the R&F, you’ll see them there starting in October. (we’ve already sent the September issue off to the printing press)  But I agree with the reader, Columbia has been on my list of countries that I’m watching, for over a year now. The currency is just so limited and fairly illiquid.  But that won’t stop me! I have a new MarketSafe CD coming out soon, get ready!The Japanese yen has been losing some ground in the past week.  As I told you in a Pfennig last week, the so-called “safe haven” destinations for money, that include yen, and Treasuries were getting sold.  Long time readers know that I threw in the towel on Japanese yen, as I kept saying that it was overvalued, and needed to weaken, and instead it would just get stronger VS the dollar. The Bank of Japan (BOJ) passed on their latest call for more stimulus at their last meeting, which didn’t help the yen.   I just think there are better currencies in Asia than yen. For the longest time, and I mean going back 20 years, when someone said they owned an Asian currency, you pretty much knew it was Japanese yen.  But it doesn’t have to be that way any longer!In that same vein. going back quite a few years. when someone said they owned a foreign currency, you pretty much knew they owned Swiss francs. (that is unless they recently took a trip to Canada or Mexico! HA!)  Swiss francs were the bees knees. But, then Switzerland was dwarfed by the Eurozone, and soon it became all about the euro. And. the Swiss National Bank (SNB) decided to hurt investors with a huge devaluation a year ago, and since then, we don’t get many people looking to buy francs.And then, I see where Bank of Canada (BOC) Gov. Carney will speak to Canadian Auto Workers Union this week.  You can bet that there will be calls to weaken the Canadian dollar / loonie. But, there’s not much the BOC can do. The loonie is stronger due to investors buying up Canadian bonds, as safe havens.  Now. in my opinion, which you know means I could be wrong, but in my opinion, Canada represents a safe haven much more than the Japanese yen, or U.S. Treasuries!  Yes, I truly understand that the size of the Japanese and U.S. bond markets dwarf Canada’s. But, given the strong banking sector in Canada, and the strong domestic demand of the economy, (we’ll see proof of that this week when Retail Sales prints) and steady government. safe haven is written all over Canada. again, that’s just my opinion!The price of Oil continues to climb higher, trading into the $96 handle this morning. There is talk now about the U.S. Gov’t releasing some of the oil reserves in an attempt to dampen the prices and prevent high energy costs, which could wipe out any gains the economy has made.Then There Was This. From The U.S. government’s debt held by foreign entities hit a record $5.2923 trillion in June, reported, citing Treasury Department data.In January 2009 the U.S. government owed $3.0717 trillion to foreigners entities, the news service added.China was the top creditor to the U.S. government, though Japanese entities were a close second.“Although the Chinese maintained their place as the top foreign owners of U.S. debt in June, they are not the top owners of U.S. debt in the world,” reported. “That distinction belongs to the U.S. Federal Reserve, which according to its July monthly report, owned $1.667 trillion in U.S. government debt in June.”Chuck again. I don’t know what scares me more. having so much of our debt held by foreigners, or by our own central bank!   I hear you saying, who do you want to own out debt, Chuck?  I don’t want debt to have to own!  Knowing that’s nearly impossible, I don’t know. I just don’t know. it’s like we’ve painted ourselves into a corner. if we step to the right, it’s bad, and if we step to the left it’s bad.  But then, I began warning about the growing debt in 2001.To recap. the currencies folded like a cheap tent on Friday to the dollar. Some second tier economic data was good for the dollar, but it had to be more than that driving the dollar higher. This morning, the currencies are attempting a move back at the dollar, as the ECB plan to buy bonds, is gaining traction, except with the Bundesbank.  The Aussie dollar is stronger this morning, and the RBA meeting minutes could give us a clue about the RBA’s feeling toward the strong A$.Currencies Today 8/20/12. American Style: A$ $1.0450, kiwi .8085, C$ $1.0115, euro 1.2310, sterling 1.5695, Swiss $1.0250, . European Style: rand 8.3120, krone 5.9370, SEK 6.6810, forint 225.65, zloty 3.3065, koruna 20.2370, RUB 32.08, yen 79.50, sing 1.2545, HKD 7.7570, INR 55.75, China 6.3590, pesos 13.10, BRL 2.0145, Dollar Index 82.63, Oil $96.13, 10-year 1.85%, Silver $28.14, and Gold $1,615.30That’s it for today. Yes, I won’t say how old my darling daughter Dawn is today, but she’s still looks like a young lady! Dawn shares a birthday, with our little Christine’s son, Jamieson. And Dawn’s college roommate, Kat, was in town yesterday, and it was her birthday, so we sang Happy Birthday to Dawn & Kat! So, birthdays all around!  The college football talk is really heating up, with all the anticipation of my beloved Missouri Tigers moving to the SEC this year. I sure hope they can be respectable in that league! It was great seeing Kat yesterday. When she attended Mizzou with Dawn, she came home with Dawn all the time, and it was like I had two daughters.  Oh, and Dawn’s husband, Jerry, wanted to be mentioned this morning too. HA!  I hope you all have a Marvelous Monday!Chuck Butler President EverBank World Markets 1-800-926-4922 read more


first_imgALABAMA VETERANS REUNIONWhen: Saturday 2-6 p.m.Where: Tuscaloosa VA Medical Center,  3701 Loop RoadHow much: FreeThe fifth annual Alabama Veterans Reunion is coming up this weekend.The Tuscaloosa VA Medical Center is hosting the event Saturday from 2 to 6 p.m.This year’s reunion is a picnic-style event instead of a formal dinner, which organizers say will create a more relaxed environment.The annual reunion gives veterans a chance to get together and celebrate outside traditional holidays.“This is an event where it’s not centered around veterans holidays,” said Director of Tourism and Development Jasmine Rainey. “Of course you have Memorial Day in May, you have Veterans Day in November, so it’s really nice to have something in the middle of the year where veterans can look forward to coming out, having a celebratory time and getting information for their families and for themselves.”The free event features musical guests, children’s play areas and free food and drinks.Several vendors on-site will be available to provide resource information to veterans and their families.last_img read more

Immunotherapy increases survival in some patients with metastatic triple negative breast cancer

first_img Source: Reviewed by James Ives, M.Psych. (Editor)Oct 22 2018Immunotherapy improves survival in some patients with metastatic triple negative breast cancer, according to late-breaking results from the IMpassion130 trial reported at the ESMO 2018 Congress in Munich.Prof. Peter Schmid, first author, said the results “will change the way triple-negative breast cancer is treated”. “Atezolizumab in combination with nab-paclitaxel is the first targeted treatment to improve survival in metastatic triple negative breast cancer,” said Schmid, Clinical Director of London’s St. Bartholomew’s Breast Cancer Centre, Barts Health NHS Trust, UK and lead of the Centre for Experimental Cancer Medicine, Barts Cancer Institute, Queen Mary University of London, UK. “It is also the first immune therapy to improve outcome in this cancer. Most of the survival benefit was in patients with PD-L1 positive tumors.”Triple negative breast cancer is the most aggressive type of breast cancer. It is relatively rare and often affects younger women. Once the disease becomes metastatic, the median survival is around 12 to 15 months. Triple negative breast cancer does not have receptors for the hormones oestrogen or the protein HER2, meaning it cannot be treated with hormone therapy or drugs targeting HER2. The main drug treatment is chemotherapy and most patients develop resistance to chemotherapy within a few months.The phase III IMpassion 130 trial enrolled 902 patients with metastatic triple negative breast cancer who had not received prior treatment for metastatic disease. Patients were randomly allocated to standard chemotherapy (nab-paclitaxel) plus atezolizumab, an antibody targeting the protein PD-L1, or to standard chemotherapy plus placebo. The two main objectives were to see whether the drug combination could slow cancer growth (progression-free survival) and prolong life (overall survival) in all patients and in those expressing PD-L1. The median follow-up was 12.9 months.The combination therapy reduced the risk of disease worsening or death by 20% in all patients and 38% in the subgroup expressing PD-L1. In the entire study population, the median progression free survival was 7.2 months with the combination and 5.5 months with chemotherapy alone, with a hazard ratio (HR) of 0.80 (p=0.0025). In the PD-L1 positive group, the median progression free survival was 7.5 months with the combination and 5.0 months with chemotherapy alone (HR 0.62, p<0.0001).More than half of patients were alive at the time of analysis, so this was an interim assessment of overall survival. In patients with PD-L1 positive tumors, the median overall survival was 25.0 months with the combination compared to 15.5 months with standard chemotherapy alone (HR 0.62). In all patients, survival was 21.3 months with the combination versus 17.6 months with chemotherapy alone which was not statistically different, likely because of the short follow-up.Related StoriesStudy reveals link between inflammatory diet and colorectal cancer riskSpecial blood test may predict relapse risk for breast cancer patientsSugary drinks linked to cancer finds studyThe proportion of patients responding to treatment (objective response rate) was higher with the combination compared to chemotherapy alone for all patients (56% versus 46%) and those with PD-L1 positive tumors (59% versus 43%).Schmid said the combination therapy was well tolerated. Most side effects were due to chemotherapy and occurred at a similar rate in both treatment groups, although there was a minor increase in nausea and cough in the combination group. Side effects related to immune therapy were rare, the most common being hypothyroidism which occurred in 17.3% of patients receiving the drug combination and 4.3% receiving chemotherapy alone.Schmid said: "Immune therapy on top of standard chemotherapy prolonged survival by ten months in patients with tumors expressing PD-L1. This combination should become a new treatment option for patients with metastatic triple negative breast cancer."Commenting on the results for ESMO, Dr Marleen Kok, Medical Oncologist, The Netherlands Cancer Institute, Amsterdam, said: "This is the first randomized phase III trial providing evidence that adding immune therapy to standard chemotherapy increases progression-free survival in metastatic triple negative breast cancer, particularly in patients with PD-L1 positive tumours, and extends overall survival in the PD-L1 positive subgroup. While the benefit in terms of progression-free survival was relatively small, around three months, the gain in overall survival in the PD-L1 positive subgroup was impressive with a ten-month benefit. Around 40% of the tumours were PD-L1 positive. The IMpassion 130 data will probably change the treatment landscape for our metastatic triple negative breast cancer patients."Kok noted that it is still not clear what the best chemotherapy backbone is for anti-PD-(L)1 treatment and that many trials are ongoing, evaluating the additional effect of anti-PD-(L)1 on top of chemotherapy in metastatic breast cancer but also for early breast cancer patients. "This should help answer the question of which chemotherapy backbone is most effective in combination with anti-PD-(L)1." she said. "We also need more studies to determine a biomarker for selecting patients most likely to benefit from this treatment."last_img read more

Measures of biochemical hypoglycemia linked to high risk of severe hypoglycemic events

first_imgReviewed by James Ives, M.Psych. (Editor)Jan 10 2019Researchers have shown that measures of biochemical hypoglycemia in fingerstick blood samples are associated with an increased risk of severe hypoglycemic events. The results of this new study, which further emphasize the dangers of hypoglycemic blood glucose levels, are published in Diabetes Technology & Therapeutics (DTT), a peer-reviewed journal from Mary Ann Liebert, Inc., publishers. Click here to read the full-text article free on the Diabetes Technology & Therapeutics (DTT) website through February 9, 2019.Related StoriesUranium toxicity might have caused obesity and diabetes in Kuwait, finds new studyAADE’s comprehensive guidance on care of children, young adults with diabetes releasedDiabetes patients experiencing empathy from PCPs have beneficial long-term clinical outcomesRoy Beck, MD, PhD, Jaeb Center for Health Research (Tampa, FL), Richard Bergenstal, MD, International Diabetes Center Park Nicollet (Minneapolis, MN), and Tonya Riddlesworth, PhD and Craig Kollman, PhD, Jaeb Center for Health Research, present their findings in the article entitled “The Association of Biochemical Hypoglycemia with the Subsequent Risk of a Severe Hypoglycemic Event: Analysis of the DCCT Data Set.” The researchers used two different levels of biochemical hypoglycemia – <70 or <54 mg/dL - to determine the relationship to severe hypoglycemic events. When either level was present, the risk of severe hypoglycemic events was significantly higher."Severe hypoglycemia is a significant hurdle for intensifying insulin therapy in patients with T1D. Beck and colleagues emphasize the increased risk of future severe hypoglycemia in patients with any level of biochemical hypoglycemia," says DTT Editor-in-Chief Satish Garg, MD, Professor of Medicine and Pediatrics at the University of Colorado Denver (Aurora).Source: read more

Sonia Rahul flew free in Mallyas airline alleges BJPSonia Rahul flew free

first_imgSHARE SHARE EMAIL SHARE Firing a fresh salvo on the Vijay Mallya issue, the BJP on Friday alleged that the Congress-led government had “raised and protected” the fugitive businessman and Rahul Gandhi and Sonia Gandhi had flown free of cost in his airlines in exchange for bank loans given to him.The BJP’s media head Anil Baluni posed eight questions to highlight the alleged help provided by the UPA government to Mallya, after the Congress claimed that Prime Minister Narendra Modi and Arun Jaitley’s “silence” on the row over the one time liquor baron’s meeting with the finance minister was an admission of guilt.“Why Rahul Gandhi does not answer these questions? Why his lips are sealed when faced with these burning questions. What can be a bigger evidence of corruption than the fact that it was the Congress government which raised and protected Mallya,” he said.Hitting out at the Congress president, Baluni said he suffers from “ideological bankruptcy and does not know what he says, does and understands“.He cited the then prime minister Manmohan Singh’s reported comments in 2011 that Kingfisher Airlines, now defunct, needed to be helped and asked if it was not true that the then finance minister P Chidambaram ignored rules to provide relief to the loss-making airline.“Is it not true that in exchange for providing (bank) loans to Mallya the then UPA chairperson and Congress president Sonia Gandhi and current Congress president Rahul Gandhi travelled free of cost in the airline’s business class,” he asked.He also repeated several allegations the ruling party has been levelling at the Congress.The two parties have been training guns at each other after Mallya claimed in London on Wednesday that he had met Jaitley before leaving India.The finance minister refuted his claim, saying he had never give him an appointment but the businessman misused his privilege as a member of Parliament to accost him in Parliament but he asked him to approach his banker.Rahul Gandhi had accused Jaitley of colluding with a criminal and sought his resignation.Congress MP P L Punia also claimed that he had seen Jaitley speaking to Mallya in Parliament’s Central Hall on March 1.BJP’s IT department head Amit Malviya claimed that Punia was “lying” under Gandhi’s instructions. Party sources have said Jaitley was busy in a number of events on that day as he had presented the Union Budget a day earlier and it was unlikely that such a meeting would have happened. Published on Kingfisher Airlines Ltd COMMENT national politics September 14, 2018 COMMENTSlast_img read more

Jai Shree Ram slogan row escalates in Bengal

first_imgThe war between West Bengal Chief Minister Mamata Banerjee and the BJP showed no signs of abating with the latter’s Jai Shree Ram slogan becoming the latest bone-of-contention.Three days ago, Banerjee lost her cool when BJP workers chantedJai Shree Ram during her visit to the North 24-Parganas. She instructed the police to take action and some people were arrested, reports said.Over the last few days more Trinamool Congress (TMC) leaders were confronted with the same chants.The BJP has also mounted a relentless attack on the Chief Minister. Video clips and memes of the incident(s) also went viral on social media.The BJP MP from Barrackpore, Arjun Singh, fired the first salvo, saying 10 lakh post cards with Jai Shree Ram written on them will be sent to the Chief Minister’s office and residence.Union Minister of State for Environment, Forest and Climate Change, Babul Supriyo, too, was critical of the TMC chief and her strong reactions. A political analyst said the slogan has become a full-fledged political issue. “CM’s strong reactions will only embolden BJP workers,” he said.Mamata’s counterBanerjee, on her part, has initiated a counter response. The Chief Minister on Sunday changed her display picture across social media platforms to Jai Hind, Jai Bangla. The picture of TMC’s official Twitter and Facebook accounts were also changed to Jai Hind, Jai Bangla with pictures of Mahatma Gandhi, Netaji Subhas Chandra Bose, Bhagat Singh, Matangini Hazra, Nobel laureate Rabindranath Tagore, and rebel poet Kazi Nazrul Islam. The TMC supremo, in a detailed Facebook post, accused the BJP of “mixing religion with politics. And alleged “divisiveness was being spread in Bengal”.She said the slogans have religious and social connotations, but are being used by the BJP and the RSS to “sell the ideology of hatred”.“We respect these sentiments. But the BJP is using these religious slogansto mix religion with politics. We do not respect this enforcement of political slogans on others in the name of so-called RSS, which Bengal never accepted.” Banerjee added she has no issues with any party slogan or a political slogan.“I have no problem with any particular slogan of political parties. Every political party has a slogan. My party has Jai Hind, Vande Mataram. The Left has Inquilab Zindabad. We respect each other,” she wrote. Reacting to the social media memes, Banerjee said “misinformation and dis-information” was being spread “to create confusion and suppress truth and reality”. Published on state politics COMMENT BJP SHARE SHARE EMAILcenter_img June 03, 2019 West Bengal SHARE COMMENTSlast_img read more

BJP threatening MLAs to switch says Abhishek Banerjee after 10 TMC councillors

first_img Asian News International KolkataJuly 13, 2019UPDATED: July 13, 2019 22:00 IST Abhishek Banerjee has accused the BJP of threatening and forcing the TMC councillors to join the saffron party. (Photo: PTI)HIGHLIGHTSBanerjee claimed that others, too, are in contact with TMCIt is BJP’s tendency to try and bloat their numbers, he saidEarlier, Mukul Roy had announced that 107 MLAs will join BJPTen Trinamool Congress councillors, who had joined the BJP recently, have rejoined the party on Saturday, party MP Abhishek Banerjee said on Saturday. He also accused the BJP of threatening and forcing the councillors to join it.”Some councillors from Kanchrapara and Halisahar had joined the BJP a few days ago. Ten of these councillors have rejoined the TMC today. They were forced and threatened to join the BJP. But now the two municipalities are back under TMC,” Abhishek Banerjee told a press conference.Several TMC MLAs and over 50 municipal councillors had last month joined the BJP after it made deep inroads in West Bengal in the Lok Sabha polls. “It is BJP’s tendency to try and bloat their numbers by giving false data,” Abhishek Banerjee said.Earlier today, BJP leader Mukul Roy had announced that as many as 107 MLAs of West Bengal are set to join the BJP. Without revealing the names of the MLAs, Mukul Roy claimed that 107 MLAs from the Communist Party of India (Marxist), Congress and the Trinamool Congress (TMC) will join the saffron party.Speaking at a press conference, Mukul Roy said that all the lawmakers are in contact with the state BJP leadership. He also said that the party has a list prepared for all the MLAs of Congress, TMC and CPM who would be joining the BJP.Reacting to Mukul Roy’s claims, Abhishek Banerjee said that the BJP leader has not been able to secure his locality councillors and has been changing his statements.”Roy is not able to secure his locality councillors. Earlier he used to say 100 MLAs now 107 MLAS, then he will say total 294 will join BJP. People who rejoined TMC today said that they were forcibly taken to Delhi to join BJP. Others are also in contact with our party, they want to come back,” Abhishek Banerjee said.The development has come just two days after at least 10 Congress MLAs in Goa switched to the BJP in presence of party working president JP Nadda and Chief Minister Pramod Sawant and amid the Karnataka crisis where 16 Congress and Janata Dal (Secular) MLAs have tendered their resignation to the Speaker.Also Read | 107 Congress, TMC, CPM MLAs will join BJP, claims Mukul RoyAlso Read | 3 Congress rebels, one BJP MLA sworn in as Goa MinistersAlso Watch | BJP leader Chandra Bose demands probe into TMC’s allegation over fake BJP membership card with Mamata’s imageFor the latest World Cup news, live scores and fixtures for World Cup 2019, log on to Like us on Facebook or follow us on Twitter for World Cup news, scores and updates.Get real-time alerts and all the news on your phone with the all-new India Today app. Download from Post your comment Do You Like This Story? Awesome! Now share the story Too bad. Tell us what you didn’t like in the comments Posted byChanchal Chauhan BJP threatening, forcing MLAs to switch, says Abhishek Banerjee after 10 TMC councillors rejoin partySeveral TMC MLAs and over 50 municipal councillors had last month joined the BJP after it made deep inroads in West Bengal in the Lok Sabha polls.advertisement Nextlast_img read more