Bert Lester Vallee, who died on May 7, 2010, was an iconoclastic figure. He would rail against the bureaucracy of institutions, especially Harvard, but would contribute substantially to their welfare – as a talented trace-metal biochemist, as an innovative medical educator, as a pioneer in academic-industrial relationships, and as creator of ingenious organizations that promoted biomedical research and collaborative international collegiality.Bert was born on June 1, 1919 to Josef and Rosa Blumenthal in Hemer, Westphalia. He attended the University of Berne where he received a B. Sc. in 1938 concentrating in zoology – later reminiscing frequently on his course in embryology there given by a student of the great developmental biologist Hans Spemann. He came to the United States immediately afterwards, the first, and only, fellow of the International Student Service of the League of Nations. He was assigned, as an advisor, to the brilliant mathematician, Richard Courant, who prepped him for entrance to NYU and its medical school. On graduation he interned at Mt. Sinai Hospital in New York City. In that era, many of the Mount Sinai teaching staff were refugees from Germany and Austria bringing with them a strong tradition in clinical diagnosis. This single year of clinical training served Bert well and the prodigious knowledge of internal medicine he derived from it was put to good use in teaching and in advising his friends on medical matters.During World War II, Bert worked in the blood preservation program of E. J. Cohn and John Edsall, founding fathers of biophysical protein chemistry. He divided his time between HMS and MIT’s radioactivity center. While working at the latter, he developed an interest in the biological functions of zinc and other transition elements in white blood cells. Consequently, after the war, he joined the MIT Spectroscopy Laboratory under the preceptorship of John R. Loofbourow (a biologist) and George Harrison (a physicist) with the purpose of developing sensitive methods for the detection and measurement of trace metals. His method of measurement, using the direct-current arc, now superseded by atomic absorption spectroscopy, was enormously demanding and Bert’s meticulous attention to its detail made his laboratory one of the few that could perform reliable analyses. During this period he met and wed Natalie T. Kugris; his lifetime companion of 63 years.Bert’s time at MIT was a yeasty one. He not only was working on methods for trace metal analysis but was also taking courses and broadening his acquaintance with like-minded scientists in this country and abroad. On a visiting fellowship at the Karolinska Institutet in Stockholm, he was able to meet the then senior biochemist of trace-metal enzymology, Hugo Theorell; some years later Theorell reciprocated by visiting Bert at his Brigham laboratory. This and other international forays played an important role in developing Bert’s conviction in the importance of international collaboration.Bert’s initial faculty appointment was through the medical department at Peter Bent Brigham Hospital. Its chief, George Thorn, was keen to have a basic research program to complement the clinical ones. In addition, Thorn was a principal advisor to the group helping Howard Hughes establish his biomedical research institute and suggested that Bert be asked to provide advice. On a visit to Oxford, where he had begun some life-long collaborations, Bert had been impressed with the structure and function of All Souls College and suggested that the nascent institute look to that organization for ideas. The form that ultimately emerged in HHMI was one of supporting independent investigators, not in residence but attached to various other institutions, whose salary and research would be funded, thus, freeing them of the chore of writing multiple grant proposals and of carrying a heavy teaching load. Bert believed that some of the structure that ultimately was put in place derived from his recommendations.George Thorn’s desire to have a basic science laboratory at the Peter Bent Brigham Hospital, was realized when the Rockefeller Foundation decided to back the construction and furnishing of a laboratory for Bert Vallee. The Biophysics Research Laboratory (BRL) was located in the bowels of the hospital, under an open general male ward. On entering from a somewhat grimy basement, one found a shiny biochemical and biophysical research space equipped with contemporary instrumentation; its centerpiece was a large Jarrell-Ash emission spectroscope built to Bert’s design. (Bert once admitted that when he first entered the finished lab he said to himself “what if zinc has nothing to do with anything”.) Thus, in 1954, began an incredibly productive period in Bert’s scientific research career.The BRL was organized along continental principles. There was a geheimrat, Bert, the laboratory chief; a scientific sub-chief; a laboratory administrator; junior faculty members, and numerous graduate students and post-doctoral fellows. Bert’s habit was to make rounds at each investigators work-station, pipe-in-mouth, prepared to enjoy any new joke to be offered as well as scientific findings. Each Thursday evening, often after a convivial dinner, all members of the lab convened to hear reports from one or more of the fellows, designated in advance. At these meetings, the conviviality of dinner was replaced by critical evaluation. Woe to any fellow whose report was not crisp and exacting. As trace metal analysis requires meticulous attention to purity and exactness in measurement, mastering the art is not for the less careful. Consequently, every fellow had to demonstrate proficiency in reproducing a standard method for determining zinc before undertaking a new research problem. Errors in accuracy, repeatability, reproducibility, and precision were all fair game for censure. While Bert was quick to criticize failures in analysis, he would equally enthuse about new findings and innovative proposals.For the next several decades, the laboratory was the seat of a number of seminal discoveries in metallo-biochemistry. The presence of zinc and its role in yeast alcohol dehydrogenase, carboxypeptidase and scores of other enzymes were elaborated. Bert’s motto by this time had become “cogito ergo zinc”. The structure and confirmation of zinc binding sites and the distinction between catalytic, regulatory and structural ones in several enzymes were delineated and generalization of the related coordination chemistry theorized in an entity called the entatic state. A unique metal-binding protein, metallothionein, was isolated from horse kidneys and, after much work, its structure defined. Thought, at first, to be a scavenger of toxic elements, it is now known to have an important role in metal homeostasis and redox activity. These advances were the result not only of Bert’s exceptional intuition and embrace of the latest technology but also his capacity to attract young scientists and clinicians of outstanding ability. Over one period, almost all of the recent medical chief residents at the PBBH had spent time in his laboratory. Many of the graduates went on to stellar careers in science or medicine in this country and abroad.Several years after the inauguration of the Biophysics Research Laboratory, Bert was promoted to Associate Professor of Medicine (then a permanent appointment). He had also assumed the position of directing the Brigham Clinical Chemistry Laboratories and was appointed Physician, a senior post at the PBBH. As a physician-scientist, whose primary activity was research rather than the care of patients, his appointment was, for some, controversial. The matter was happily resolved on Eugene Kennedy’s arrival as chairman of Biological Chemistry who arranged for Bert to assume a tenured spot in that department. Shortly thereafter, George Berry called Bert to the Paul C. Cabot chair in recognition of his contributions to the School. Bert, who had been unsure of his relationship with Berry (as he subsequently was with other academic administrators), when told about this claims to have replied “Dean Berry, I am speechless” – to which Berry retorted “the ultimate triumph of my career”.On appointment to the Department of Biological Chemistry, Bert was asked to organize a Saturday morning clinic which, running in parallel with the first-year course in biochemistry, would present examples of biochemical abnormalities in disease. He accepted this assignment with great enthusiasm and, being a natural showman, turned them into scientific theater. Cases in gout, porphyria, and other chemical disorders were presented, often with exotic graphics that were the stock-in-trade of his lectures. A number of former students remember these presentations with delight.Bert had also thought quite a bit about how best to combine science with medicine in the instruction of medical students. He was given permission, with their consent, to oversee the 2nd year course-of-study for a small group. Using case-based and tutorial instruction (foreseeing a curricular change introduced in the 1980s) he led the group through a combination of patho-physiology and physical diagnosis. The course was a great success and was repeated at least once. In addition, Bert fashioned a course in human biology and medicine for hospital-based scientists. This, too, was a success as the students performed well on examination by others on the clinical faculty.In addition to these courses, Bert chaired the committee on whether HMS should adopt an MD-PhD program. The faculty was of mixed opinion on this matter, some claiming that one doctorate was sufficient and that research training in the biomedical specialties could better be obtained in a post-MD fellowship. Bert believed the additional course-work and discipline of writing a thesis for obtaining a PhD valuable in itself; he felt he had benefitted a good deal from his courses at MIT and was a strong advocate of the combined degree. The committee was divided in sentiment. Bert, discovering that some opponents took long weekends, devised to hold meetings late on Friday when they would be absent. He claims this maneuver allowed to him to obtain an endorsement of the concept and, thus, enabled him to write the MSTP-NIH training grant proposal that was funded to support the program. Bert was its first director. Although, Harvard was a latecomer to this activity it has flourished and is now a leader in attracting students.In the early 1970s, the first of two chance events occurred that were to markedly alter the nature and support of the laboratory’s research activities. Since its inception, the BRL had an advisory board, one of whose members was Arthur Kornberg. On a visit to Judah Folkman, he afterwards came to see Bert. Kornberg was aware of the BRL’s expertise in protein chemistry and suggested that this could be of great benefit to Judah who was having difficulty isolating his postulated but elusive tumor-associated angiogenesis factors. The two laboratories combined forces and, with assistance from the NCI, pursued the isolation. However, the project was much more difficult than anticipated as the amounts of material available were miniscule and the lab facilities unable to scale up to the level required. Bert, then a consultant to Monsanto, was aware of the company’s fledgling interest in biotechnology. He offered them the opportunity to gain valuable experience in this newly emerging field by becoming partners in the angiogenesis effort. Thus, in 1974, Harvard and Monsanto embarked on a radical departure from conventional academic research by entering into a joint venture catalyzed by Bert and Monsanto Vice-President, Monte Throdahl. This was an academic-industrial enterprise on a large scale, perhaps the first of its kind in terms of funding and duration. It provided Monsanto with a “window on biology” and facilitated their conversion from a producer of bulk chemicals to a leader in agricultural bioengineering. In exchange, the company provided HMS with the first floor of the Seeley G. Mudd building, three professorships, and twelve years of substantial indirect-cost revenue. (Bert and administrative dean, Henry Meadow, drove a hard bargain.) It was overseen by an external review committee and was the basis of new institutional policies concerning intellectual property. It was also the source of much contentious discussion in academic circles as to the role of industrial affiliation in universities.From the large pots of medium that Monsanto had used to culture cancer cells, the BRL ultimately extracted and identified angiogenin a ribonuclease-like molecule that is one of a number of angiogenic factors. The research also was the basis for a ribonuclease inhibitor that was patented, providing School and Laboratory with additional income. As a result, the laboratory was able to expand its research into other directions.Because Bert, as well as many of his associates, had a background in medicine, the BRL always had an interest in bringing its fundamental findings into clinical utility, what today might be called translational research. On the basis of the lab’ s discoveries, one of the first enzymes, whose blood level was employed in the diagnosis of myocardial infarction, was lactate dehydrogenase. When it was found that ethylene glycol was a competitive inhibitor of alcohol dehydrogenase, treatment of the poison’s toxicity was instituted with ethanol. One of us (WECW), as a member of the lab, took the lead in these clinical studies.Sometime in the late 1970s, the Brigham and Women’s Hospital, in the hope of raising money for a new research building, introduced Bert to Edgar Bronfman, CEO of Joseph E. Seagram & Sons and head of the Samuel Bronfman Foundation. Bronfman was intrigued by Bert’s interest in alcohol metabolism but he was not in the least interested in funding a building. Charles Giel, Bronfman’s personal physician, was present at the first Vallee-Bronfman meeting and suggested afterwards that an alternative would be to support scientific research rather than construction. In time, Bronfman agreed. Legal technicalities required that the corpus of the $5.8M gift remain invested in the Bronfman Foundation, which would then contribute, according to expenditure, to a 501(C)(3) entity other than Harvard University for the uses of Bert’s laboratory. To circumvent this complication, Roger Moore (then counsel to the University) proposed that a tax-exempt endowment be set up for the benefit of the President and Fellows of Harvard College that would disburse the funds. Known as The Endowment for Research in Human Biology, it was governed by a board of directors that included the incorporator (Bert) as well as representatives from Harvard and the Bronfman Foundation. An advisory committee was also formed to review and evaluate the progress of the work; chaired by Bert, its members included three independent scientists. By careful husbanding of expenses by Bert and astute investment management by the Bronfman Foundation and, later, by an independent financial advisor, more than $10M was ultimately made available for the conduct of research.The pursuit of a treatment for alcoholism was aided by another seemingly chance event. Wing-Ming Keung had been a post-doctoral fellow, under Bert in 1980-81, studying metalloenzymes. When he left to join the faculty at a university in Hong Kong, he continued to be supported by the Endowment. While there, he developed an interest in Chinese herbal medicine. These two interests merged when he found that extracts from the plant Kudzu, long used in the treatment of alcoholism, also inhibited enzymes that metabolize ethanol. He, subsequently, returned to the BRL where he derived from the extract an inhibitor of aldehyde dehydrogenase (2nd step in the breakdown of ethanol) called daidzin. Animal models of alcoholism subsequently showed that administration of the compound turned rats and hamsters away from preferring alcohol to water. Pursuit of this compound and other derivatives for human use, under license, was taken up by a sequence of biotech companies. It is currently being investigated by Gilead Sciences.Bert and Natalie Vallee had no children and lived relatively frugally. Their sole indulgence was horseback riding in Arizona and Montana. The rest of their disposable income, derived from Bert’s salary and consultancies with chemical and petroleum companies (for whom trace-metals are of importance), was invested under the guidance of a wise counselor. Thus, with a substantial nest-egg, he and his wife looked for means to perpetuate their interests. They decided to create a foundation promoting dialogue between active and prominent biomedical scientists around the world, first by sponsoring visiting professorships among institutions in which Bert had developed close collaborations and second by organizing biannual meetings of this group. Since its origin 15 years ago, 25 senior scientists have spent a month’s period visiting at host institutions, using the time to meet with colleagues in their fields as well as to establish research collaborations. The biannual meetings have been an opportunity for the Vallee visiting scholars to hear about each other’s work and to develop a convivial fellowship.Bert Vallee had an overwhelming persona. This strength of character kept him active despite repeated bouts of Guillain-Barré paralysis that rendered him physically handicapped. His single-minded concentration on achieving his goals, coupled with a sharp intelligence, allowed him to accomplish much. He cherished his friendships, professional and secular, but could heap opprobrium on those he felt stood against him. Bert relished bringing his friends together and entertaining them at home, at his clubs, in Alsace, in a Tuscan conference village, and in meetings of the Vallee Visiting Professors under the aegis of his and Natalie’s foundation. And it is particularly this group of familiars that will remember him with admiration and affection.Respectfully submitted,Earl DavieKenneth H. FalchukHenry RosovskyJames F. RiordanWarren E. C. WackerS. James Adelstein, Chairperson
Decorated skulls will rest on an altar in Saint Mary’s Student Center Atrium this week to commemorate Dia de los Muertos, or Day of the Dead, and honor loved ones who have passed away. La Fuerza, a group that celebrates Latino culture, hosted an event to decorate the skulls Monday evening in the Student Center. Senior Areli Bautista, a member of La Fuerza, said people sometimes misunderstand the holiday’s purpose. “In Mexico and other parts of the world, the Day of the Dead is a day to remember loved ones and bring cultures together,” Bautista said. “This is a day of celebration, not mourning.” Students decorated the skulls with bright colors like blue and green for the display. “By creating and decorating things like skulls with vibrant colors, rather than black, dark colors, it reminds us that the Day of the Dead is a celebration of loved ones,” Bautista said. The celebration takes place every year on Nov. 1 and 2 during the Catholic holidays of All Saints’ Day and All Souls’ Day. The skulls will remain on the altar in the Atrium until Friday. Bautista said Mass will be celebrated at 9 p.m. Wednesday in the Le Mans Holy Spirit Chapel. “The prayer services are for remembering loved ones that have passed and celebrating the lives they had,” she said. “That is the true meaning of Dia de los Muertos.”
NEW YORK — A scare about possible salmonella contamination has caused Aldi’s to voluntarily recall peaches.Aldi announced a recall of peaches from Wawona Packing Company, including both loose and bagged peaches,. Target is also in the process of removing peaches from its stores.Officials in various states are investigating a multi-state outbreak of Salmonella Enteritidis infections linked to consumption of fresh, whole peaches supplied by Wawona Packing Company.Ill people have reported purchasing peaches from Aldi, Target, and possibly other retail locations. Health officials recommend throwing out or returning fresh, whole peaches supplied by Wawona Packing Company. Do not eat them. Other peaches (including frozen or canned peaches) are not known to be affected. Fresh peaches supplied by other companies are not known to be affected. If people are unsure whether the peaches they bought are supplied by Wawona, they should contact the retail location where they were purchased. If they have any doubts about where their peaches came from, they should not eat them and should throw them away.Symptoms of Salmonella infection include diarrhea, abdominal pain and fever. Symptoms usually begin within 12 to 96 hours after exposure, but they can begin up to two weeks after exposure. Infections usually clear in five to seven days, but about 28 percent of laboratory-confirmed cases require hospitalization. Share:Click to share on Facebook (Opens in new window)Click to share on Twitter (Opens in new window)Click to email this to a friend (Opens in new window)
Share:Click to share on Facebook (Opens in new window)Click to share on Twitter (Opens in new window)Click to email this to a friend (Opens in new window),TRUMP IS A DRAFT DODGER AND HAS NO RESPECT FOR THE MILITARY !!,“Orange Man Bad” said msm NPC, I mean TV loving Paul,Liberalism is a disease!Biden is a pervert and is discusting! Image by Rory Pollaro/WNYNewsNow.WEST ELLICOTT — Supporters of President Donald Trump who don’t have access to a boat can still rally on his behalf thanks to a road cruise to be held starting noon on Saturday.Event planners say the cruise will circle Chautauqua Lake. Participants are asked to meet in the former K-Mart parking lot prior to the noon start.The route will take drivers and riders west on Route 394 and back toward Jamestown on Route 430.Organizers encourage people to participate in their trucks, cars, motorcycles, classic cars or “anything street legal.” Participants are asked to decorate their vehicles with pro Trump signs, flags and bumper stickers. They are asked to don red shirts for the event.“Come support our president and support our essential workers from the Police, fire and volunteer departments along with everyone who has supported our country in a positive way,” organizers said.Two recent pro Trump boat rallies on Chautauqua Lake drew more than 100 water craft and sky divers.
Johanns emphasized that this finding poses no risk to human health, adding that the findings should not affect trade discussions with other countries, because those discussions involve far younger cattle. Because BSE has a long incubation period, experts believe it is nearly impossible for cattle younger than 30 months to have infective levels of disease. Because of the conflicting findings of the IHC and Western blot tests, further tests will now be conducted, authorities said. Jun 13, 2005 (CIDRAP News) After one inconclusive and one negative test for bovine spongiform encephalopathy (BSE), a tissue sample from a downer cow has shown a positive result with a third test, authorities announced in a late-evening news conference Jun 10. The Western blot result was a “weak positive,” Clifford said. “As a result of that and the unusualness of this case, it’s going to require additional testing before we can confirm one way or another whether this is truly BSE or not.” USDA teleconference transcript This round of testing involved three cows whose initial rapid tests were inconclusive, according to a news release from the US Animal and Plant Health Inspection Service (APHIS). A second test, called an immunohistochemistry (IHC) test was conducted, and all three animals tested negative for the progressively debilitating, fatal disease caused by a folded protein called a prion. Clifford and USDA Secretary Mike Johanns both emphasized that the conflicting test results are not an indictment of the US screening system for BSE. “In the case of this animal, it was a nonambulatory downer animal and as such it was banned from the food supply,” Clifford said. “It was taken to a facility that only handles downer animals unsuitable for human consumption and the carcass was incinerated.” Samples from the cow were stored for further testing. A sample from the cow will be sent to a World Organization for Animal Health (OIE) recognized laboratory for BSE in Weybridge, England, said John Clifford, chief veterinary officer for APHIS during a telephone news conference late on Jun 10. In addition, USDA will be conducting further tests over the next several days. Authorities sought this round of testing because one of the initial rapid tests had shown a positive reaction, APHIS noted. A sample from the same downer cow, which means a cow that couldn’t walk, tested positive with the Western blot. The other two samples tested negative in the third round. As a follow-up, the US Department of Agriculture (USDA) Office of the Inspector General (OIG) recommended the week of June 5 that all three samples be subjected to a third round of testing. This test, the Western blot, differs from the other two, the APHIS release explained. It is an internationally recognized confirmatory test for BSE, as is the IHC test. “After we receive additional tests on this animal, we will determine what further steps need to be taken and what changes if any are warranted in our surveillance program,” he added. “We have not confirmed a case of BSE in the US at this time,” Clifford said. Indications are that the cow, described as an older beef cow, was born in the United States. See also: In all, some 375,000 cattle have been tested for BSE since the surveillance program began in June 2004, authorities said. The tests focus on downer cattle and cattle showing signs of neurological problems. BSE tests explainedhttp://ec.europa.eu/food/fs/bse/bse21_en.html
Jetta Klijnsma, state secretary for social affairs in the Netherlands, has warned Dutch pension funds that their deteriorating financial position does not yet justify changing the rules.In a recent consultation with Parliament, she suggested the government could change its mind at a scheduled assessment of the situation in May, but she categorically ruled out any adjustment of the discount rate for liabilities.Klijnsma said she wanted to assess pension funds’ position on a quarterly basis, using figures from pensions regulator De Nederlandsche Bank (DNB).While she conceded that the outlook for this year and 2017 was “not rosy”, she said it was not yet serious enough for immediate measures. She pointed out that beleaguered pension funds, thanks to the new financial assessment framework (nFTK), were not required to apply rights cuts straightaway. During the meeting with Parliament, Klijnsma said she expected the outcome of a survey into individual pensions accrual combined with collective risk sharing – currently being conducted by the Social and Economic Council (SER) – could be presented in March.She also announced that she would start talks with the Pensions Register to factor in a longevity-dependent age for the state pension AOW into its overview of pension rights.The register currently draws its prediction for combined pension rights from a retirement age of no more than 67. However, the social security bank (SVB) – responsible for the payout of AOW benefits – already takes a retirement age into account of 69 years and nine months for somebody born in 1975.
The Parliamentary Standing Committee on Water Resources Ministry yesterday recommended the Bangladeshi Government to complete the dredging of Buriganga, Shitalakkhya and Turag rivers on a priority basis, United News of Bangladesh (UNB) reports. The committee came up with the suggestion at its 36th meeting held at the Jatiya Sangsad, chaired by Ramesh Chandra Sen.The Parliamentary Watchdog also discussed the implementation progress of a flood control dam-cum-road project in the area of Bangladesh Economic Zones Authority (BEZA) at Mirsarai in Chittagong, UNB said.During the meeting, the committee was informed that the works on Teesta Barrage Project, Phase-II (Unit-1) will complete soon.Committee members State Minister for Water Resources Muhammad Nazrul Islam, AKM Fazlul Haque, Faridul Haque Khan, Rejwan Ahammad Taufiq, Mustafizur Rahaman Chowdhury and Selina Jahan Lita attended the meeting.[mappress mapid=”25155″]
RelatedPosts Moses laments Europa League loss Europa League: StarTimes to broadcast Man U, Inter Milan quarterfinal matches Moses eyes Europa League success Former Wigan Athletic star Victor Moses is the latest player to donate to a crowdfunding appeal aiming to help save the administration-hit club after making a “significant” contribution.Moses, 29, played for the Latics between 2010 and 2012. The Nigeria international made 80 appearances for Wigan in that time and scored nine goals, before being sold to Chelsea over the summer of 2012.During his time at Stamford Bridge, Moses has won the Premier League, FA Cup and the Europa League and spent the second half of last season on loan at Italian side Inter Milan.The Wigan Athletic Supporters Club has now revealed that the ex-Latics winger is the latest current or former player to have donated to a crowdfunding appeal set up by fans.A tweet from the Supporters Club thanked Moses for pledging a “significant donation” to its Save Our Club campaign.The crowdfunding appeal is seeking to generate £750,000 and Moses’ contribution – speculated to be £20,000 (N10 million) after an anonymous pledge for that amount appeared on the crowdfunder – has taken the appeal to within £100,000 of its target. The campaign is aiming to give Wigan fans as strong as possible a voice on the club’s board in its future ownership.Moses got in touch with the Supporters Club earlier this week to help save the League One club and aided Wigan fans in their efforts.Caroline Molyneux, chair of the Wigan Athletic Supporters’ Club, said the donation showed “incredible” generosity from the former Latics star who will “always be welcome” at the club.Caroline said: “Wow – what can we say? When Victor got in touch to say he wanted to help by donating such a substantial amount, I just couldn’t believe what I was hearing – it’s such an incredible gesture.“Victor wanted to make the donation and remain anonymous but we simply had to make sure he gets the recognition he deserves. “Victor’s contribution has taken us past £650,000 and to within £100,000 of our next target of £750,000.“We are so thankful to Victor for his support. He is an excellent footballer, a true role model and someone we always enjoyed watching at the DW Stadium – he will always be welcome back here, even more so now!”Tags: Victor MosesWigan
Press Association The Lancashire trainer travels with a pair of seasoned all-weather performers to tackle the unique event on the strand. Seamster, twice a winner at Lingfield this summer, looks to have a leading chance in the opening Tote Mobile Betting Handicap under Colin Keane. Richard Ford has his first runners in Ireland when saddling two at Laytown beach. My Son Max, who was successful last time out at Beverley, also appears a live contender in the Barry Matthews Appreciation Handicap, with Katie Walsh taking the mount in the amateur contest. “We’ve got a couple of sporting owners and they want to give it a try,” said Ford. “They are both slightly better in than they are on their all-weather marks at home, but they can’t run in their normal headgear because of the rules. “The surface is a lot different, but we’ve given them a canter down on our local beach and done what we can. “They seem in good form and we have two very capable jockeys booked, so we’ll give it our best shot.”
Ireland will face Argentina in Cardiff in Sunday’s quarter-final, with full-back Kearney warning Joe Schmidt’s men not to get ahead of themselves. Ireland topped their pool at World Cup 2011, only to fall foul of a rampant Wales in a 22-10 quarter-final defeat – and Kearney is determined not to let history repeat itself. “We were here four years ago and topped the group,” said Kearney. “Everyone thought we were brilliant, we thought we were brilliant and we went out and got pumped by a really good Wales team. “So we don’t have much time to sit around and think about this great performance we had yesterday, we have to move on really quickly. “Bar the Australians the Argentinians have probably been the most impressive side. “Their ability to score points has been very, very strong throughout the tournament. “We’ve got to make sure we’re next-task focused as quickly as we can be. “We’re a very different team from four years ago. “Our mental strength on how we approach games on a week-to-week basis has improved massively. “And again this will be a big test for us in terms of how much of a week-to-week team we actually are.” Ian Madigan has been branded Ireland’s Paul Gascoigne after his tearful reaction to Sunday’s 24-9 World Cup victory over France. Fly-half Madigan bawled his eyes out at the final whistle of Ireland’s biggest victory over France since 1975, that secured a quarter-final against Argentina. The Leinster pivot stepped squarely out of Johnny Sexton’s shadow after the British and Irish Lions fly-half trudged out of the France clash with a groin strain. Press Association Madigan bossed Ireland’s backline to come of Test-match age, drawing comparisons from his team-mates with former England midfielder Gascoigne’s famous waterworks at the 1990 FIFA World Cup in Italy. “Yeah the boys are calling him Gazza inside there!” said full-back Rob Kearney. “I think it was a day where Ian Madigan really stood up for us. “We needed him to come on and really take control of things and he did, it was brilliant.” Gascoigne’s tears were shed in frustration at receiving a yellow card that would have ruled him out of the final, as England battled a semi-final with West Germany. The Germans triumphed on penalties in Turin that night, with Gazza not the only England star to shed a tear. Madigan’s Millennium Stadium moment was for altogether different reasons, the magnitude of his performance hitting home as referee Nigel Owens sounded full-time. The ever-popular 26-year-old has drawn fine praise from his team-mates, but Rob Kearney conceded Ireland can ill afford to dwell on a job well done against Les Bleus.